4-DAMP

Cat. No. 0482

4-DAMP C21H26INO2
 [1952-15-4]

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Chemical Name: 1,1-Dimethyl-4-diphenylacetoxypiperidinium iodide

Biological Activity

Antagonist at the M3 cholinergic receptor. [3H]-4-DAMP selectively labels M1 and M3 receptors.

Technical Data

M.Wt:
451.33
Formula:
C21H26INO2
Solubility:
Soluble to 25 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
1952-15-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Michel et al (1989) Direct labelling of rat M3-muscarinic receptors by [3H]4-DAMP. Eur.J.Pharmacol. 166 459. PMID: 2806372.

Barlow and Shepherd (1986) A further search for selective antagonists at M2- muscarinic receptors. Br.J.Pharmacol. 89 837. PMID: 3814912.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for 4-DAMP include:

Fonseca et al (2015) Diadenosine tetraphosphate contributes to carbachol-induced tear secretion. Purinergic Signal 11 87. PMID: 25398705.

Mans et al (2014) An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats. J Neurophysiol 112 2388. PMID: 25143547.

Nedvetsky et al (2014) Parasympathetic innervation regulates tubulogenesis in the developing salivary gland. Dev Cell 30 449. PMID: 25158854.

Pacini et al (2014) M2muscarinic receptors inhibit cell proliferation and migration in urothelial bladder cancer cells. Cancer Biol Ther 15 1489. PMID: 25482946.

Placeres-Uray et al (2014) M2 Muscarinic acetylcholine receptor modulates rat airway smooth muscle cell proliferation. World Allergy Organ J 6 22. PMID: 24377382.

Jahchan et al (2013) A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov 3 1364. PMID: 24078773.

Hodges et al (2012) Signaling pathways used by EGF to stimulate conjunctival goblet cell secretion. Exp Eye Res 103 99. PMID: 22975404.

Do you know of a great paper that uses 4-DAMP from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: 4-DAMP, supplier, Muscarinic, M3, antagonists, Receptors, Acetylcholine, Ach, Tocris Bioscience, M3 Receptor Antagonist products

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