(±)-HIP-A

Cat. No. 2217

HIP-A C6H8N2O4 [227619-64-9]

Price and Availability

For (±)-HIP-A pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (±)-3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-4-carboxylic acid

Biological Activity

Potent, non-competitive excitatory amino acid transporter (EAAT) blocker. Preferentially inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.6 μM) rather than [3H]L-glutamate uptake (IC50 = 18 μM). Moderately selective; displays no affinity for NMDA and metabotropic glutamate receptors, and low affinity for AMPA and kainate receptors (IC50 values are 43 and 8 μM respectively).  .

Technical Data

M.Wt:
172.14
Formula:
C6H8N2O4
Solubility:
Soluble to 10 mM in water
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
227619-64-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Funicello et al (2004) Dissociation of [3H]glutamate uptake from glutamate-induced [3H]D-Aspartate release by 3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-4-carboxylic acid and 3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-6-carboxylic acid, two conformationally constrained aspartate and glutamate analogs. Mol.Pharmacol. 66 522. PMID: 15322243.

Conti et al (1999) Synthesis of new bicyclic analogues of glutamic acid. Tetrahedron 55 5623.

Conti et al (1999) Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists. J.Med.Chem. 42 4099. PMID: 10514280.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses (±)-HIP-A from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: HIP-A, supplier, Potent, non-competitive, EAAT, inhibitors, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, Tocris Bioscience, Glutamate Transporter Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Updated in 2015, this guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

divider line

Huntington's Disease: Pathophysiology and Clinical Prospects

Huntington's Disease Life Science Poster

Written by Annalena Wieland and Nicholas Allen, this poster summarizes the intracellular signaling pathways implicated in the pathology of HD Request copy or view PDF today.

divider line

Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

Schizophrenia Life Science Poster

'Schizophrenia - Emerging Targets and Therapeutic Strategies' provides a summary of the targets and pathways representing the most promising strategies to pursue for novel drug development. Request copy today.

divider line

New Products in this Area

ML 352 hydrochloride

High affinity and selective presynaptic choline transporter (CHT) inhibitor

TC-T 6000

Potent equilibrative nucleoside transporter 4 (ENT4) inhibitor

(R)-Citalopram oxalate

Enantiomer of escitalopram oxalate (Cat. No. 1427)

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Physiology 2016

Physiology 2016

July 29 - 31, 2016

Dublin, Ireland

Booth: 26