Cat. No. 0213
Chemical Name: D-Aminosuccinic acid
Biological ActivityEndogenous NMDA receptor agonist with similar activity to the L-isomer (L-aspartic acid, Cat. No. 0214). Also a non-metabolizable substrate for EAA uptake systems. Modulates melatonin synthesis in the pineal gland.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ishio et al (1998) D-Aspartate modulates melatonin synthesis in rat pinealocytes. Neurosci.Lett. 249 143. PMID: 9682837.
Hashimoto et al (1997) Free D-aspartate and D-serine in the mammalian brain and periphery. Prog.Neurobiol. 53 325. PMID: 9247969.
Olverman et al (1988) Structure/activity relations of NMDA receptor ligands as studied by their inhibition of 3H-D-AP5 binding in rat brain membranes. Neuroscience 26 17. PMID: 2901691.
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Keywords: D-Aspartic acid, supplier, NMDA, agonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Tocris Bioscience, NMDA Receptor Agonist products