des-His1-[Glu9]-Glucagon (1-29) amide
Cat. No. 2216
Biological ActivityGlucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitro. Blocks added glucagon-induced hyperglycemia in normal rabbits without affecting glycogenolysis in vivo. Also blocks endogenous glucagon-induced hyperglycemia in streptozocin diabetic rats.
(Modifications: Thr-28 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Huypens et al (2000) Glucagon receptors on human islet cells contribute to glucose competence of insulin release. Diabetologia 43 1012. PMID: 10990079.
Unson et al (1989) Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist. Peptides 10 1171. PMID: 2560175.
Unson et al (1987) Synthetic peptide antagonists of glucagon. Proc.Natl.Acad.Sci.USA 84 4083.
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Citations are publications that use Tocris products. Selected citations for des-His1-[Glu9]-Glucagon (1-29) amide include:
Weston et al (2015) Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2). Acta Pharmacol Sin 290 23009. PMID: 26198634.
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Keywords: des-His1-[Glu9)-Glucagon (1-29) amide, supplier, Glucagon, receptor, antagonists, antagonist, receptors, Tocris Bioscience, Glucagon Receptor Antagonist products
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