ABT 724 trihydrochloride

Cat. No. 2214

ABT 724 trihydrochloride C17H19N5.3HCl [587870-77-7]

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Chemical Name: 2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole trihydrochloride

Biological Activity

Potent dopamine D4 receptor partial agonist (EC50 = 12.4 nM; 61% efficacy vs. dopamine). Has no agonist activity at D2 receptors (EC50 > 10 μM). Selective in rats in vivo; produces penile erection following i.c.v. administration; increases intracavernosal pressure and potentiates the proerectile effects of sildenafil following s.c. administration. Displays minimal side effects.

Technical Data

M.Wt:
402.75
Formula:
C17H19N5.3HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
587870-77-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Brioni et al (2004) Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats. Proc.Natl.Acad.Sci.USA 101 6758.

Cowart et al (2004) Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction. J.Med.Chem. 47 3853. PMID: 15239663.

Stewart et al (2004) Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning. J.Med.Chem. 47 2348. PMID: 15084133.

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Keywords: ABT 724 trihydrochloride, supplier, Potent, selective, D4, partial, agonists, proerectile, Dopamine, Receptors, dopaminergic, ABT724, trihydrochloride, Tocris Bioscience, D4 Receptor Agonist products

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