Cat. No. 0104
Chemical Name: DL-2-Amino-7-phosphonoheptanoic acid
Biological ActivityFirst generation phosphono NMDA antagonist. Anticonvulsant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Meldrum and Chapman (1994) Competitive NMDA antagonists as drugs. In The NMDA Receptor (2nd edition). Eds. G. L. Col 457.
Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65. PMID: 7042024.
If you know of a relevant reference for DL-AP7 please let us know.
Citations are publications that use Tocris products. Selected citations for DL-AP7 include:
Stevens et al (2010) Light-evoked NMDA receptor-mediated currents are reduced by blocking D-serine synthesis in the salamander retina. Neuroreport 21 239. PMID: 20101193.
Gustafson et al (2007) Endogenous D-serine contributes to NMDA-receptor-mediated light-evoked responses in the vertebrate retina. J Neurophysiol 98 122. PMID: 17507508.
Do you know of a great paper that uses DL-AP7 from Tocris? If so please let us know.
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Keywords: DL-AP7, supplier, Selective, Specific, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlu, Ionotropic, Tocris Bioscience, NMDA Receptor Antagonist products