Cat. No. 2213
Chemical Name: 2-[(3,3-Diphenylpropyl)amino]acetam
Biological ActivitySelective, non-competitive NMDA receptor antagonist (IC50 = 5 μM); binds to the receptor-associated ion channel and prevents glutamate-induced Ca2+ influx. Displays neuroprotective activity in vivo. Brain-penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Planells-Cases et al (2002) A novel N-methyl-D-aspartate receptor open channel blocker with in vivo neuroprotectant activity. J.Pharmacol.Exp.Ther. 302 163. PMID: 12065713.
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Citations are publications that use Tocris products. Selected citations for N20C hydrochloride include:
Roy et al (2014) Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase. J Biol Chem 9 e101883. PMID: 25007337.
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Keywords: N20C hydrochloride, supplier, Non-competitive, NMDA, receptor, open-channel, blockers, glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Tocris Bioscience, NMDA Receptor products