Cat. No. 2893
Chemical Name: (2S,3S)-N-(2-Methoxyphenyl)methyl-2
Biological ActivityPotent and selective non-peptide NK1 receptor antagonist. Attenuates substance P-induced salivary response and inhibits neurogenic inflammation in vivo.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Bang et al (2003) Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury. J.Pharmacol.Exp.Ther. 305 31. PMID: 12649350.
Lembeck et al (1992) The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation. Br.J.Pharmacol. 105 527. PMID: 1378337.
Snider et al (1991) A potent nonpeptide antagonist of the substance P (NK1) receptor. Science 251 435. PMID: 1703323.
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Citations are publications that use Tocris products. Selected citations for CP 96345 include:
Silva et al (2015) Spinal blockage of P/Q- or N-type voltage-gated calcium channels modulates functional and symptomatic changes related to haemorrhagic cystitis in mice. Br J Pharmacol 172 924. PMID: 25298144.
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Keywords: CP 96345, supplier, Potent, selective, nonpeptide, NK1, receptors, antagonists, tachykinin, neurokinin, CP96345, Pfizer, Tocris Bioscience, NK1 Receptor Antagonist products
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