Cat. No. 2206
Alternative Names: 2-Palm-Gl, 2-PG
Chemical Name: 2-Hydroxy-1-(hydroxymethyl)ethyl hexadecanoic acid ester
Biological ActivityEndogenous fatty acid glycerol ester that enhances activity of 2-arachidonylglycerol (Cat. No. 1298). Does not bind to CB1 or CB2 cannabinoid receptors, but potentiates the apparent binding of 2-AG and increases its ability to inhibit adenylyl cyclase. Enhances in vivo cannabinoid effects of 2-AG following combined administration with 2-linoleoylglycerol.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Walker et al (2002) Endocannabinoids and related fatty acid derivatives in pain modulation. Chem.Phys.Lipids 121 159. PMID: 12505698.
Gallily et al (2000) 2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-α production in murine macrophages, and in mice. Eur.J.Pharmacol. 406 R5. PMID: 11011050.
Ben-Shabat et al (1998) An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonyl-glycerol cannabinoid activity. Eur.J.Pharmacol. 353 23. PMID: 9721036.
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Keywords: 2-Palmitoylglycerol, supplier, Endogenous, lipid, enhances, activity, 2-AG, cannabinoid, receptors, fatty, acid, glycerol, ester, 2-arachidonylglycerol, Tocris Bioscience, Other Cannabinoid products
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Potent and selective CB2 partial agonist; orally biovailable
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