STEARDA

Cat. No. 2204

STEARDA C26H45NO3 [105955-10-0]

Price and Availability

For STEARDA pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: N-Stearoyldopamine

Chemical Name: N-[2-(3,4-Dihydroxyphenyl)ethyl]octadecanamide

Biological Activity

Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB1 receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC50 > 25 μM). However, potentiates TRPV1-mediated effects of NADA in vitro and in vivo; enhances effects on intracellular Ca2+ (EC50 lowered 3-fold) and nociception. Also inhibits arachidonate 5-lipoxygenase (IC50 = 16 nM).

Technical Data

M.Wt:
419.64
Formula:
C26H45NO3
Solubility:
Soluble to 5 mM in ethanol with gentle warming
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
105955-10-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

De Petrocellis et al (2004) Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels. Br.J.Pharmacol. 143 251. PMID: 15289293.

Chu et al (2003) N-Oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J.Biol.Chem. 278 13633. PMID: 12569099.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses STEARDA from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: STEARDA, supplier, Endogenous, lipid, active, vivo, Enhances, effects, endovanilloids, TRPV1, receptors, inhibitors, inhibits, 5-lipoxygenase, Vanillioid, Receptors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, Lipoxygenase, Oxidase, Oxygenases, Oxidases, 5-LOX, Tocris Bioscience, TRPV products

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

divider line

New Products in this Area

PF 05105679

Selective TRPM8 blocker

M 084 hydrochloride

TRPC4/5 channel blocker; antidepressant and anxiolytic

A 425619

Potent TRPV1 antagonist

RN 9893 hydrochloride

Potent and selective TRPV4 antagonist

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.