Cat. No. 2203

PALDA C24H41NO3 [136181-87-8]

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Alternative Name: N-Palmitoyldopamine

Chemical Name: N-[2-(3,4-Dihydroxyphenyl)ethyl]hexadecanamide

Biological Activity

Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB1 receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC50 > 25 μM). However, potentiates TRPV1-mediated effects of NADA; lowers EC50 from ~ 90 to ~ 30 nM.

Technical Data

Soluble to 5 mM in ethanol with gentle warming
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

De Petrocellis et al (2004) Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels. Br.J.Pharmacol. 143 251. PMID: 15289293.

Chu et al (2003) N-Oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J.Biol.Chem. 278 13633. PMID: 12569099.

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Keywords: PALDA, supplier, Endogenous, lipid, potentiates, effects, endovanilloids, TRPV1, receptors, Vanillioid, Receptors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, Tocris Bioscience, TRPV products

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