Zatebradine hydrochloride

Cat. No. 2202

Zatebradine hydrochloride C26H36N2O5.HCl [91940-87-3]

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Alternative Name: UL-FS 49

Chemical Name: 3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride

Biological Activity

Bradycardic agent that produces use-dependent inhibition of hyperpolarization-activated current If (HCN channel) in sinoatrial node cells (EC50 = 480 nM) and Purkinje fibres. Displays negative chronotropic activity in isolated guinea pig atria (EC50 of 13.4 μM).

Technical Data

M.Wt:
493.04
Formula:
C26H36N2O5.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
91940-87-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Romanelli et al (2005) Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current. Bioorg.Med.Chem. 13 1211. PMID: 15670930.

Goethals et al (1993) Use-dependent block of the pacemaker current I(f) in rabbit sinoatrial node cells by zatebradine (UL-FS 49). On the mode of action of sinus node inhibitors. Circulation 88 2389. PMID: 8222132.

Van Bogaert et al (1990) Use- and frequency-dependent blockade by UL-FS 49 of the if pacemaker current in sheep cardiac Purkinje fibres. Eur.J.Pharmacol. 187 241. PMID: 2272362.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Zatebradine hydrochloride include:

Bender et al (2007) Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. J Neurosci 27 4697. PMID: 17460082.

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View Related Products by Product Action

Keywords: Zatebradine hydrochloride, supplier, Bradycardic, agent, blocks, If, pacemaker, current, Channel, modulators, VDAC, ULFS49, HCN, blockers, Tocris Bioscience, HCN Channel Blocker products

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