Mithramycin A

Cat. No. 1489

Mithramycin A C52H76O24 [18378-89-7]

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Chemical Name: (1S)-5-Deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy-β-D-arabino-hexopyranosyl)-β-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-β-D-ribo-hexopyranosyl-(1.fwdarw.3)-O-2,6-dideoxy-β-D-lyxo-hexopyranosyl-(1.fwdarw.3)-2,6-dideoxy-β-D-arabino-hexopyranosyl)oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-1-O-methyl-D-threo-2-pentulose

Biological Activity

Anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.

Technical Data

M.Wt:
1085.16
Formula:
C52H76O24
Solubility:
Soluble to 50 mM in DMSO
Purity:
>95 %
Storage:
Desiccate at -20°C
CAS No:
18378-89-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Demicheli and Garnier-Suillerot (1991) Mithramycin cannot bind to left-handed poly(dG-m5dC) in the presence of Mg2+ ion. Biochem.Biophys.Res.Commun. 177 511. PMID: 1828342.

Ray et al (1990) Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene. Am.J.Med.Sci. 300 203. PMID: 2147360.

Miller et al (1987) Mithramycin selectively inhibits transcription of G-C containing DNA. Am.J.Med.Sci. 294 388. PMID: 2962490.

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Citations are publications that use Tocris products. Selected citations for Mithramycin A include:

Oh et al (2015) Arachidonic acid promotes skin wound healing through induction of human MSC migration by MT3-MMP-mediated fibronectin degradation. J Neurosci 6 e1750. PMID: 25950480.

Siddesha et al (2014) Acetylsalicylic acid inhibits IL-18-induced cardiac fibroblast migration through the induction of RECK. J Cell Physiol 229 845. PMID: 24265116.

Huang et al (2012) Prostaglandin E2 increases fibroblast gene-specific and global DNA methylation via increased DNA methyltransferase expression. FASEB J 26 3703. PMID: 22645246.

Corsini et al (2007) Role of SP-1 in SDS-induced adipose differentiation related protein synthesis in human keratinocytes. Gene Regul Syst Bio 1 207. PMID: 19936089.

Duverger et al (2004) The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF). Cell Death Dis 90 2025. PMID: 15138489.

Do you know of a great paper that uses Mithramycin A from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Mithramycin A, supplier, inhibitors, inhibits, DNA, RNA, polymerases, MithramycinA, antibiotics, Tocris Bioscience, RNA/DNA Polymerase Inhibitor products

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