Cat. No. 1489
Chemical Name: (1S)-5-Deoxy-1-C-[(2S,3S)-7-[[2,6-d
Biological ActivityAnticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Demicheli and Garnier-Suillerot (1991) Mithramycin cannot bind to left-handed poly(dG-m5dC) in the presence of Mg2+ ion. Biochem.Biophys.Res.Commun. 177 511. PMID: 1828342.
Ray et al (1990) Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene. Am.J.Med.Sci. 300 203. PMID: 2147360.
Miller et al (1987) Mithramycin selectively inhibits transcription of G-C containing DNA. Am.J.Med.Sci. 294 388. PMID: 2962490.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Mithramycin A include:
Siddesha et al (2014) Acetylsalicylic acid inhibits IL-18-induced cardiac fibroblast migration through the induction of RECK. J Cell Physiol 229 845. PMID: 24265116.
Huang et al (2012) Prostaglandin E2 increases fibroblast gene-specific and global DNA methylation via increased DNA methyltransferase expression. FASEB J 26 3703. PMID: 22645246.
Corsini et al (2007) Role of SP-1 in SDS-induced adipose differentiation related protein synthesis in human keratinocytes. Gene Regul Syst Bio 1 207. PMID: 19936089.
Do you know of a great paper that uses Mithramycin A from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Mithramycin A, supplier, inhibitors, inhibits, DNA, RNA, polymerases, MithramycinA, antibiotics, Tocris Bioscience, RNA/DNA Polymerase Inhibitor products