tcY-NH2

Cat. No. 1488

tcY-NH2 trans-Cinnamoyl-Tyr-Pro-Gly-Lys-Phe-NH2

Price and Availability

For tcY-NH2 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: (trans-Cinnamoyl)-YPGKF-NH2

Biological Activity

Selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.

Technical Data

M.Wt:
739.87
Formula:
C40H49N7O7
Sequence:
YPGKF

(Modifications: Tyr-1 = trans-Cinnamoyl-Tyr, Phe-5 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
327177-34-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
Select another batch:

References are publications that support the products' biological activity.

Hollenberg et al (2004) Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br.J.Pharmacol. 143 443. PMID: 15451771.

Hollenberg and Saifeddine (2001) Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. Can.J.Physiol.Pharmacol. 79 439. PMID: 11405248.

Ma et al (2001) Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonist. Br.J.Pharmacol. 134 701. PMID: 11606309.

If you know of a relevant reference for tcY-NH2 please let us know.

Citations are publications that use Tocris products. Selected citations for tcY-NH2 include:

Carrim et al (2015) Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα. Br J Cancer 6 640. PMID: 26569550.

Sales et al (2015) Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis. Redox Biol 34 346. PMID: 24469043.

Do you know of a great paper that uses tcY-NH2 from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: tcY-NH2, supplier, Selective, PAR4, antagonists, Receptors, Protease-Activated, proteinase-activated, Tocris Bioscience, Protease-Activated Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

Cardiovascular Life Science Poster

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy or view PDF today.

divider line

New Products in this Area

ELA-14 negative control

Negative control for ELA-14 (Cat.No.6293).

ELA-14 (human)

Potent apelin (APJ) receptor agonist

Retrobradykinin

Reverse analog of Bradykinin

TASP 0390325

Potent and selective V1B receptor antagonist; orally bioavailable

ML 233

Non-peptide apelin receptor agonist

Sign-up for new product e-alerts
divider line

ISSCR 2017

Win a $1,000 travel grant

ISSCR Travel Grant 2017

Bio-Techne is offering 10 travel grants of $1,000 for ISSCR 2017.