AY-NH2

Cat. No. 1487

AY-NH2 Ala-Tyr-Pro-Gly-Lys-Phe-NH2

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Alternative Name: AYPGKF-NH2

Biological Activity

Selective PAR4 receptor agonist peptide. Stimulates platelet aggregation in vitro (EC50 = 15 μM). Exhibits an increase in paw thickness in the paw edema inflammation model in vivo.

Technical Data

M.Wt:
680.8
Formula:
C34H48N8O7
Sequence:
AYPGKF

(Modifications: Phe-6 = C-terminal amide)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
352017-71-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Hollenburg et al (2004) Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br.J.Pharmacol. 143 443. PMID: 15451771.

Hollenberg and Saifeddine (2001) Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. Can.J.Physiol.Pharmacol. 79 439. PMID: 11405248.

Faruqi et al (2000) Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. J.Biol.Chem. 275 19728. PMID: 10779527.

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Keywords: AY-NH2, supplier, selective, PAR4, agonists, receptors, protease-activated, proteinase-activated, peptide, Tocris Bioscience, Protease-Activated Receptor Agonist products

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