GR 231118

Cat. No. 1486

GR 231118 Ile-Glu-Pro-Dpr-Tyr-Arg-Leu-Arg-Tyr-NH2 Ile-Glu-Pro-Dpr-Tyr-Arg-Leu-Arg-Tyr-NH2 (Disulfide bridges: 2 - 4*, 4 - 2*)

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Alternative Names: 1229U91, GW 1229

Biological Activity

Potent neuropeptide Y (NPY) Y1 receptor antagonist (pA2 = 10 and 10.5 at rY1 and hY1, receptors respectively). Also a potent and selective NPY Y4 receptor agonist (pEC50 values are 6.0, 8.6 and 6.1 for rY2, hY4 and rY5 receptors respectively). Suppresses food intake in rats in vivo. Also has affinity for neuropeptide FF (NPFF) receptors in vitro (Ki = 43-73 nM).

Technical Data

M.Wt:
2352.77
Formula:
C110H170N34O24
Sequence:
IEPXYRLRY IEPXYRLRY*

(Modifications: X = Dpr, Amide Bridge = 2 - 4*, 4 - 2*, Tyr-9 = C-terminal amide)

Storage:
Desiccate at -20°C
CAS No:
158859-98-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Mollereau et al (2001) Agonist and antagonist activities on human NPFF2 receptors of the NPY ligands GR231118 and BIBP3226. Br.J.Pharmacol. 133 1. PMID: 11325787.

Ishihara et al (1998) A potent neuropeptide Y antagonist, 1229U91, suppressed spontaneous food intake in Zucker fatty rats. Am.J.Physiol. 274 R1500. PMID: 9612420.

Parker et al (1998) GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists. Eur.J.Pharmacol. 349 97. PMID: 9669502.

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Keywords: GR 231118, supplier, NPFF, receptor, ligands, NPY, Y1, antagonists, Y4, agonists, Neuropeptide, FF, GR231118, npffr1, npffr2, npff1, npff2, GW1229, 1229, U91, neuropeptides, Tocris Bioscience, NPY Receptor products

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