PNU 22394 hydrochloride

Cat. No. 2201

PNU 22394 hydrochloride C13H16N2.HCl [15923-42-9]

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Chemical Name: 1,2,3,4,5,6-Hexahydro-6-methyl-azepino[4,5-b]indole hydrochloride

Biological Activity

Potent 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist. Non-selective between 5-HT2 receptor subtypes (Ki values are 18, 18 and 66 nM for human recombinant 5-HT2C, 5-HT2A and 5-HT2B receptors respectively). Reduces food intake in rats following subcutaneous administration and displays anorexigenic effects in humans.

Technical Data

M.Wt:
236.74
Formula:
C13H16N2.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
15923-42-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Jensen et al (2013) Design, synthesis and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive properties. J.Med.Chem. 56 1211.

McCall et al (2001) PNU-22394, a 5-HT2C receptor agonist, reduces feeding in rodents and produces weight loss in humans. Soc.Neurosci.Abstr. 27 309.

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