GR 89696 fumarate

Cat. No. 1483

GR 89696 fumarate C19H25Cl2N3O3.C4H4O4 [126766-32-3]

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Chemical Name: 4-[(3,4-Dichlorophenyl)acetyl]-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylic acid methyl ester fumarate

Biological Activity

Highly potent and selective κ-opioid agonist (IC50 = 0.04 nM) that may be selective for the putative κ2 receptor. Anti-nociceptive and neuroprotective in vivo.

Technical Data

Soluble to 25 mM in water with gentle warming and to 100 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Butelman et al (2001) GR89,696: a potent κ-opioid agonist with subtype selectivity in rhesus monkeys. J.Pharmacol.Exp.Ther. 298 1049. PMID: 11504802.

Naylor et al (1993) A potent new class of κ-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino)methyl]piperazines. J.Med.Chem. 36 2075. PMID: 8393489.

Birch et al (1991) Neuroprotective actions of GR89696, a highly potent and selective κ-opioid receptor agonist. Br.J.Pharmacol. 103 1819. PMID: 1657267.

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Keywords: GR 89696 fumarate, supplier, Subtype-selective, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, GR89696, fumarate, Tocris Bioscience, κ Opioid Receptor Agonist products

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