PD 160170

Cat. No. 2200

PD 160170 C18H17N3O4S [181468-88-2]

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Chemical Name: 6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine

Biological Activity

Potent, selective non-peptidic neuropeptide Y1 receptor antagonist (Ki = 48 nM); selective over Y2 and Y5 receptors (Ki > 10 μM). Antagonizes NPY-mediated inhibition of cAMP accumulation in SK-N-MC cells (IC50 = 8.2 nM).

Technical Data

M.Wt:
371.41
Formula:
C18H17N3O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
181468-88-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Wielgosz-Collin et al (2002) 8-Amino-5-nitro-6-phenoxyquinolines:potential non-peptidic neuropeptide Y receptor ligands. J.Enz.Inhib.Med.Chem. 17 449.

Wright et al (1996) 8-Amino-6-(arylsulphonyl)-5-nitroquinolines: novel nonpeptide neuropeptide Y1 receptor antagonists. Bioorg.Med.Chem.Lett. 6 1809.

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Citations are publications that use Tocris products. Selected citations for PD 160170 include:

Zambrano et al (2015) Density of α4β2* nAChR on the surface of neurons is modulated by chronic antagonist exposure. Pharmacol Res Perspect 3 e00111. PMID: 25729578.

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Keywords: PD 160170, supplier, Selective, non-peptide, NPY, Y1, antagonists, Neuropeptide, Y, Receptors, PD160170, neuropeptides, Tocris Bioscience, NPY Receptor Antagonist products

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