Cat. No. 2200
Chemical Name: 6-[[2-(1-Methylethyl)phenyl]]sulfon
Biological ActivityPotent, selective non-peptidic neuropeptide Y1 receptor antagonist (Ki = 48 nM); selective over Y2 and Y5 receptors (Ki > 10 μM). Antagonizes NPY-mediated inhibition of cAMP accumulation in SK-N-MC cells (IC50 = 8.2 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Wielgosz-Collin et al (2002) 8-Amino-5-nitro-6-phenoxyquinolines:potential non-peptidic neuropeptide Y receptor ligands. J.Enz.Inhib.Med.Chem. 17 449.
Wright et al (1996) 8-Amino-6-(arylsulphonyl)-5-nitroquinolines: novel nonpeptide neuropeptide Y1 receptor antagonists. Bioorg.Med.Chem.Lett. 6 1809.
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Citations are publications that use Tocris products. Selected citations for PD 160170 include:
Zambrano et al (2015) Density of α4β2* nAChR on the surface of neurons is modulated by chronic antagonist exposure. Pharmacol Res Perspect 3 e00111. PMID: 25729578.
Atasoy et al (2012) Deconstruction of a neural circuit for hunger. Physiol Rep 488 172. PMID: 22801496.
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Keywords: PD 160170, supplier, Selective, non-peptide, NPY, Y1, antagonists, Neuropeptide, Y, Receptors, PD160170, neuropeptides, Tocris Bioscience, NPY Receptor Antagonist products
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