Mifepristone

Cat. No. 1479

Mifepristone C29H35NO2 [84371-65-3]

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Alternative Names: RU 486, RU 38486

Chemical Name: (11β,17β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one

Biological Activity

Selective antagonist at progesterone (PR) and glucocorticoid (GR) receptors in vitro and in vivo. Is a silent antagonist at PR and has a higher affinity than progesterone. Has higher affinity for GR than dexamethasone (Cat. No. 1126).

Technical Data

M.Wt:
429.6
Formula:
C29H35NO2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol with gentle warming
Purity:
>99 %
Storage:
Store at RT
CAS No:
84371-65-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Mao et al (1992) Molecular mechanism of RU 486 action: a review. Mol.Cell.Biochem. 109 1. PMID: 1614417.

Gagne et al (1985) RU 38486: a potent antiglucocorticoid in vitro and in vivo. J.Steroid Biochem. 23 247. PMID: 2864478.

Schrieber et al (1983) Binding of the anti-progestin RU 486 to rat ovary steroid receptors. Contraception 28 77. PMID: 6627946.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Mifepristone include:

Lee et al (2016) The Anti-apoptotic Effect of Ghrelin on Restraint Stress-Induced Thymus Atrophy in Mice. Immune Network 16 242. PMID: 27574503.

Reinhardt et al (2015) Sox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo. EMBO J 34 1572. PMID: 25908840.

Zarif et al (2015) Androgen receptor non-nuclear regulation of prostate cancer cell invasion mediated by Src and matriptase. Biol Reprod 6 6862. PMID: 25730905.

Liu et al (2014) Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents. Mol Brain 7 32. PMID: 24758222.

Sze et al (2013) The role of glucocorticoid receptors in dexamethasone-induced apoptosis of neuroprogenitor cells in the hippocampus of rat pups. World J Gastroenterol 2013 628094. PMID: 23401645.

Dorey et al (2012) Stress-induced memory retrieval impairments: different time-course involvement of corticosterone and glucocorticoid receptors in dorsal and ventral hippocampus. Neuropsychopharmacology 37 2870. PMID: 22948976.

Kodithuwakku et al (2012) Wnt activation downregulates olfactomedin-1 in Fallopian tubal epithelial cells: a microenvironment predisposed to tubal ectopic pregnancy. Lab Invest 92 256. PMID: 21968811.

Shikatani et al (2012) Inhibition of proliferation, migration and proteolysis contribute to corticosterone-mediated inhibition of angiogenesis. PLoS One 7 e46625. PMID: 23056375.

Butts et al (2011) Glucocorticoid receptors in the prefrontal cortex regulate stress-evoked dopamine efflux and aspects of executive function. Proc Natl Acad Sci U S A 108 18459. PMID: 22032926.

Luoma et al (2011) Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity. Steroids 76 845. PMID: 21371490.

Schwendt and McGinty (2010) Amphetamine up-regulates activator of G-protein signaling 1 mRNA and protein levels in rat frontal cortex: the role of dopamine and glucocorticoid receptors. J Neurosci 168 96. PMID: 20298760.

Urbanet et al (2010) Analysis of insulin sensitivity in adipose tissue of patients with primary aldosteronism. J Neurophysiol 95 4037. PMID: 20484481.

Zhang (2010) Hepatocyte growth factor system in the mouse uterus: variation across the estrous cycle and regulation by 17-β-estradiol and progesterone. Neuroscience 82 1037. PMID: 20147731.

Campioni et al (2009) Stress-induced changes in nucleus accumbens glutamate synaptic plasticity. Oncotarget 101 3192. PMID: 19357347.

Mayanagi et al (2008) Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton. J Biol Chem 283 31183. PMID: 18772142.

Wood et al (2006) Facilitation of cardiac vagal activity by CRF-R1 antagonists during swim stress in rats. Neuropsychopharmacology 31 2580. PMID: 16710322.

Yang et al (2005) Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake. Mediators Inflamm 25 4288. PMID: 15858055.

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Keywords: Mifepristone, supplier, Glucocorticoid, progesterone, antagonists, glucocorticoid, Receptors, RU486, RU38486, Tocris Bioscience, Progesterone Receptor Antagonist products

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