Cat. No. 1479
Alternative Names: RU 486, RU 38486
Chemical Name: (11β,17β)-11-[4-(Dimethylamino)phenyl
Biological ActivitySelective antagonist at progesterone (PR) and glucocorticoid (GR) receptors in vitro and in vivo. Is a silent antagonist at PR and has a higher affinity than progesterone. Has higher affinity for GR than dexamethasone (Cat. No. 1126).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Mao et al (1992) Molecular mechanism of RU 486 action: a review. Mol.Cell.Biochem. 109 1. PMID: 1614417.
Gagne et al (1985) RU 38486: a potent antiglucocorticoid in vitro and in vivo. J.Steroid Biochem. 23 247. PMID: 2864478.
Schrieber et al (1983) Binding of the anti-progestin RU 486 to rat ovary steroid receptors. Contraception 28 77. PMID: 6627946.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Mifepristone include:
Reinhardt et al (2015) Sox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo. EMBO J 34 1572. PMID: 25908840.
Liu et al (2014) Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents. Mol Brain 7 32. PMID: 24758222.
Dorey et al (2012) Stress-induced memory retrieval impairments: different time-course involvement of corticosterone and glucocorticoid receptors in dorsal and ventral hippocampus. Neuropsychopharmacology 37 2870. PMID: 22948976.
Kodithuwakku et al (2012) Wnt activation downregulates olfactomedin-1 in Fallopian tubal epithelial cells: a microenvironment predisposed to tubal ectopic pregnancy. Lab Invest 92 256. PMID: 21968811.
Shikatani et al (2012) Inhibition of proliferation, migration and proteolysis contribute to corticosterone-mediated inhibition of angiogenesis. PLoS One 7 e46625. PMID: 23056375.
Butts et al (2011) Glucocorticoid receptors in the prefrontal cortex regulate stress-evoked dopamine efflux and aspects of executive function. Proc Natl Acad Sci U S A 108 18459. PMID: 22032926.
Luoma et al (2011) Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity. Steroids 76 845. PMID: 21371490.
Mayanagi et al (2008) Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton. J Biol Chem 283 31183. PMID: 18772142.
Wood et al (2006) Facilitation of cardiac vagal activity by CRF-R1 antagonists during swim stress in rats. Neuropsychopharmacology 31 2580. PMID: 16710322.
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Keywords: Mifepristone, supplier, Glucocorticoid, progesterone, antagonists, glucocorticoid, Receptors, RU486, RU38486, Tocris Bioscience, Progesterone Receptor Antagonist products
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