FIT

Cat. No. 1480

FIT C23H27N3OS [85951-63-9]

Price and Availability

For FIT pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Fentanyl isothiocyanate

Chemical Name: N-[1-[2-(4-Isothiocyanatophenyl)ethyl]-4-piperidinyl]-N-phenylpropanamide

Biological Activity

Selective and irreversible δ-opioid agonist (EC50 = 8 nM); acts by alkylating the receptor.

Technical Data

M.Wt:
393.55
Formula:
C23H27N3OS
Solubility:
Soluble to 100 mM in ethanol and to 10 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
85951-63-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Schoffelmeer et al (1988) μ-, δ- and κ-opioid receptor-mediated inhibition of neurotransmitter release and adenylate cyclase activity in rat brain slices: studies with fentanyl isothiocyanate. Eur.J.Pharmacol. 154 169. PMID: 2906610.

Rothman et al (1985) Evidence that the delta-selective alkylating agent, fit, alters the mu-noncompetitive opiate delta binding site. Neuropeptides 6 227. PMID: 2991807.

Rice et al (1983) Irreversible ligands with high selectivity toward δ or μ opiate receptors. Science 220 314. PMID: 6132444.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses FIT from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: FIT, supplier, Irreversible, δ-opioid, delta-opioid, agonists, DOP, Receptors, OP1, Tocris Bioscience, δ Opioid Receptor Agonist products

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs Request copy or view PDF today.

divider line

Appetite Modulation

Written by S. Tucci et al

Peptides Involved in Appetite Modulation Scientific Review

Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis. View PDF today.

divider line

Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

divider line

Mechanisms of Addiction

Addiction Life Science Poster

Written by Prof David Nutt, this poster summarizes the brain circuits and neurotransmitter systems that are affected by the main classes of addictive drugs. Request copy or view PDF today.

divider line

Bio-Techne Events

IVBM 2016

IVBM 2016

October 30 - November 3, 2016

Boston, MA, USA

Booth: 2