Cat. No. 1480
Alternative Name: Fentanyl isothiocyanate
Chemical Name: N-[1-[2-(4-Isothiocyanatophenyl)eth
Biological ActivitySelective and irreversible δ-opioid agonist (EC50 = 8 nM); acts by alkylating the receptor.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Schoffelmeer et al (1988) μ-, δ- and κ-opioid receptor-mediated inhibition of neurotransmitter release and adenylate cyclase activity in rat brain slices: studies with fentanyl isothiocyanate. Eur.J.Pharmacol. 154 169. PMID: 2906610.
Rothman et al (1985) Evidence that the delta-selective alkylating agent, fit, alters the mu-noncompetitive opiate delta binding site. Neuropeptides 6 227. PMID: 2991807.
Rice et al (1983) Irreversible ligands with high selectivity toward δ or μ opiate receptors. Science 220 314. PMID: 6132444.
If you know of a relevant reference for FIT please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses FIT from Tocris? If so please let us know.
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Keywords: FIT, supplier, Irreversible, δ-opioid, delta-opioid, agonists, DOP, Receptors, OP1, Tocris Bioscience, δ Opioid Receptor Agonist products
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