Cat. No. 1431
Alternative Names: [D-Pen2,5]Enkephalin, [D-Pen2,D-Pen5]Enkephalin
Biological ActivityPrototypical selective δ-opioid receptor agonist peptide. Inhibits electrically stimulated contraction of mouse vas deferens in vitro (EC50 = 5.2 nM), and is antinociceptive in vivo.
(Modifications: X = D-Pen, Disulfide bridge between 2 - 5)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Fraser et al (2000) Supraspinal antinociceptive response to [D-Pen2,5]-enkephalin (DPDPE) is pharmacologically distince from that to other δ-agonists in the rat. J.Pharmacol.Exp.Ther. 295 1135. PMID: 11082450.
Chandrakumar et al (1992) Analogs of the δ opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions. J.Med.Chem. 35 2928. PMID: 1323677.
Clark et al (1986) [D-Pen2,D-Pen5]enkephalin (DPDPE): a δ-selective enkephalin with low affinity for μ1 opiate binding sites. Eur.J.Pharmacol. 128 303. PMID: 3025000.
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Citations are publications that use Tocris products. Selected citations for DPDPE include:
Leal et al (2013) Peripheral δ-opioid receptors attenuate the exercise pressor reflex. PLoS One 305 H1246. PMID: 23934854.
Saloman et al (2011) Activation of peripheral δ-opioid receptors leads to anti-hyperalgesic responses in the masseter muscle of male and female rats. Am J Physiol Heart Circ Physiol 190 379. PMID: 21664434.
Peart et al (2007) Impaired p38 MAPK/HSP27 signaling underlies aging-related failure in opioid-mediated cardioprotection. J Mol Cell Cardiol 42 972. PMID: 17407780.
Do you know of a great paper that uses DPDPE from Tocris? If so please let us know.
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Keywords: DPDPE, supplier, Selective, agonists, δ-opioid, delta-opioid, d-opioid, DOP, Receptors, OP1, delta-receptor, Tocris Bioscience, δ Opioid Receptor Agonist products
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