Gap 27

Cat. No. 1476

Gap 27 Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile

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Biological Activity

Peptide derived from connexin 43 that is a selective gap junction blocker. Attenuates ACh-induced arterial relaxation and reduces K+-mediated smooth muscle repolarization in endothelium-intact vessels in vitro.

Technical Data

M.Wt:
1304.55
Formula:
C60H101N15O17
Sequence:
SRPTEKTIFII
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
198284-64-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Richards et al (2001) Suppression of K+-induced hyperpolarization by phenylephrine in rat mesenteric artery: relevance to studies of endothelium-derived hyperpolarizing factor. Br.J.Pharmacol. 134 1. PMID: 11522590.

Ko et al (2000) Biochemical and functional characterization of intercellular adhesion and gap junctions in fibroblasts. Am.J.Physiol.Cell Physiol. 279 C147. PMID: 10898726.

Chaytor et al (1998) Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. J.Physiol. 508 561. PMID: 9508817.

If you know of a relevant reference for Gap 27 please let us know.

Citations are publications that use Tocris products. Selected citations for Gap 27 include:

Westphalen et al (2014) Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity. Nature 506 503. PMID: 24463523.

Do you know of a great paper that uses Gap 27 from Tocris? If so please let us know.

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Keywords: Gap 27, supplier, Selective, gap, junction, blockers, Connexins, Gap, Channels, modulators, Gap27, Tocris Bioscience, Gap Channel Blocker products

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