(-)-[3R,4S]-Chromanol 293B

Cat. No. 1475

(-)-[3R,4S]-Chromanol 293B C15H20N2O4S [163163-24-4]

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Chemical Name: N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide

Biological Activity

Enantiomer that selectively inhibits the slow component of delayed rectifier K+ current (IKs). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC50 values are 1.36 and 9.6 μM respectively). Has negligible inhibitory action at KV11.1 (hERG) channels (IC50 > 30 μM). Racemate Chromanol 293B (Cat. No. 1412) also available.

Technical Data

M.Wt:
324.39
Formula:
C15H20N2O4S
Solubility:
Soluble to 100 mM in ethanol with gentle warming and to 100 mM in DMSO with gentle warming
Purity:
>99 %
Storage:
Store at RT
CAS No:
163163-24-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Lerche et al (2001) Molecular impact of MinK on the enantiospecific block of IKs by chromanols. Br.J.Pharmacol. 131 1503. PMID: 11139424.

Seebohm et al (2001) A kinetic study on the stereospecific inhibition of KCNQ1 and IKs by the chromanol 293B. Br.J.Pharmacol. 134 1647. PMID: 11739240.

Yang et al (2000) Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels. J.Pharmacol.Exp.Ther. 294 955. PMID: 10945846.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for (-)-[3R,4S]-Chromanol 293B include:

Purtell et al (2012) The KCNQ1-KCNE2 K+ channel is required for adequate thyroid I- uptake. Neuropharmacology 26 3252. PMID: 22549510.

Ma et al (2011) High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. FASEB J 301 H2006. PMID: 21890694.

Do you know of a great paper that uses (-)-[3R,4S]-Chromanol 293B from Tocris? If so please let us know.

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Keywords: (-)-[3R,4S]-Chromanol 293B, supplier, IKs, blockers, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, (-)-[3R4S]-Chromanol293B, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Blocker products

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