Suramin hexasodium salt

Cat. No. 1472

Suramin hexasodium salt C51H34N6Na6O23S6 [129-46-4]

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Chemical Name: 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt

Biological Activity

Non-selective P2 purinergic antagonist. Also blocks calmodulin binding to recognition sites and G protein coupling to G protein-coupled receptors. Increases open probability of ryanodine receptor (RyR) channels. Anticancer and antiviral agent.

Technical Data

M.Wt:
1429.15
Formula:
C51H34N6Na6O23S6
Solubility:
Soluble to 50 mM in water and to 10 mM in DMSO
Storage:
Store at RT
CAS No:
129-46-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Hill et al (2004) Functional regulation of the cardiac ryanodine receptor by suramin and calmodulin involves multiple binding sites. Mol.Pharmacol. 65 1258. PMID: 15102954.

Klinger et al (2001) Suramin and the suramin analogue NF307 discriminate among calmodulin-binding sites. Biochem.J. 355 827. PMID: 11311147.

Beindl et al (1996) Inhibition of receptor/G protein coupling by suramin analogues. Mol.Pharmacol. 50 415. PMID: 8700151.

Charlton et al (1996) PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors. Br.J.Pharmacol. 118 704. PMID: 8762097.

Voogd et al (1993) Recent research on the biological activity of suramin. Pharmacol.Rev. 45 177. PMID: 8396782.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Suramin hexasodium salt include:

Fonseca et al (2015) Diadenosine tetraphosphate contributes to carbachol-induced tear secretion. Purinergic Signal 11 87. PMID: 25398705.

Naviaux et al (2015) Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model. Mol Autism 6 1. PMID: 25705365.

Rosa et al (2015) Neuron-glia signaling in developing retina mediated by neurotransmitter spillover. J Mol Neurosci 4. PMID: 26274565.

Tang et al (2015) Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP. J Neurosci 35 3016. PMID: 25698739.

Naviaux et al (2014) Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy. Transl Psychiatry 4 e400. PMID: 24937094.

Malmersjö et al (2013) Neural progenitors organize in small-world networks to promote cell proliferation. J Pharmacol Exp Ther 110 E1524. PMID: 23576737.

Naviaux et al (2013) Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model. PLoS One 8 e57380. PMID: 23516405.

Hazleton et al (2012) Purinergic receptors are required for HIV-1 infection of primary human macrophages. J Immunol 188 4488. PMID: 22450808.

Ibáñez et al (2012) A high throughput scintillation proximity imaging assay for protein methyltransferases. Comb Chem High Throughput Screen 15 359. PMID: 22256970.

Manohar et al (2012) ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation. J Leukoc Biol 92 787. PMID: 22753954.

Rodríguez-Zayas et al (2012) Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue. Am J Physiol Heart Circ Physiol 46 167. PMID: 21647706.

Thrane et al (2011) Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proc Natl Acad Sci U S A 108 846. PMID: 21187412.

Verma et al (2005) Modulation of agonist binding to human dopamine receptor subtypes by L-prolyl-L-leucyl-glycinamide and a peptidomimetic analog. Elife 315 1228. PMID: 16126839.

Price et al (2004) Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons. Br J Pharmacol 142 257. PMID: 15155534.

Do you know of a great paper that uses Suramin hexasodium salt from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Suramin hexasodium salt, supplier, Non-Selective, P2, antagonists, P2X, P2Y, Uncouples, G, proteins, from, receptors, heterotrimeric, purinoceptors, ryanodine, receptors, ion, channels, Tocris Bioscience, Purinergic (P2X) Receptor Antagonist products

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