O-2093

Cat. No. 1446

O-2093 C34H43Cl2NO3 [439080-01-0]

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Chemical Name: N-(bis-3-chloro-4-hydroxybenzyl)-5Z,8Z,11Z,14Z-eicosatetraenamide

Biological Activity

Inhibitor of anandamide uptake (IC50 = 17.3 μM) with little or no activity at CB1, CB2, TRPV1 and FAAH. Intravenous administration inhibits limb spasticity in mice with chronic relapsing experimental allergic encephalomyelitis (CREAE).

Licensing Information

Sold under license from VCU-IPF

Technical Data

M.Wt:
584.62
Formula:
C34H43Cl2NO3
Solubility:
Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)
Storage:
Desiccate at -20°C
CAS No:
439080-01-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Ligresti et al (2006) New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis. Br.J.Pharmacol. 147 83. PMID: 16284631.

Di Marzo et al (2002) A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid. J.Pharmacol.Exp.Ther. 300 984. PMID: 11861807.

Griffin et al (2001) Activity of a novel anandamide analog suggests a non-CB1, non-VR1 site of action. 2001 Symposium on the Cannabinoids, International .

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Keywords: O-2093, supplier, inhibitors, inhibits, anandamide, reuptake, AMT, Transporters, Cannabinoids, Monoamine, Neurotransmitter, Tocris Bioscience, Cannabinoid Transporter Inhibitor products

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