Cat. No. 1445
Alternative Name: NAGly
Chemical Name: N-(1-oxo-5Z,8Z,11Z,14Z-eicosatetrae
Biological ActivityEndogenous anandamide-like compound. Lacks affinity for CB1 receptors (Ki > 10 μM), VR1 receptors (EC50 > 10 μM) and anandamide transporters (IC50 > 50 μM) but causes hot-plate analgesia in mice when given orally, and suppresses tonic inflammatory pain. Also endogenous GlyT2 inhibitor.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Edington et al (2009) Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport. J.Biol.Chem. 284 36424. PMID: 19875446.
Huang et al (2001) Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. J.Biol.Chem. 276 42639. PMID: 11518719.
Burnstein et al (2000) Oxidative metabolism of anandamide. Prostaglandins Other Lipid Mediat. 61 29. PMID: 10785540.
Sheskin et al (1997) Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor. J.Med.Chem. 40 659. PMID: 9057852.
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Keywords: N-Arachidonylglycine, supplier, endocannabinoids, Suppresses, pain, vivo, Receptors, Tocris Bioscience, Other Cannabinoid products
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Potent and selective CB2 partial agonist; orally biovailable
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