Cat. No. 1439
Chemical Name: Ammoniated ruthenium oxychloride
Biological ActivityBlocks Ca2+ uptake and release from mitochondria, and Ca2+ release from ryanodine-sensitive intracellular stores. Also blocks cell membrane-located capsaicin-activated cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels to inhibit neurotransmitter release.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Szallasi and Blumberg (1999) Vanilloid (capsaicin) receptors and mechanisms. Pharmacol.Rev. 51 159. PMID: 10353985.
Xu et al (1999) Ruthenium red modifies the cardiac and skeletal muscle Ca2+ release channels (ryanodine receptors) by multiple mechanisms. J.Biol.Chem. 274 32680. PMID: 10551824.
Amann and Maggi (1991) Ruthenium red as a capsaicin antagonist. Life Sci. 49 849. PMID: 1715010.
Bernardi et al (1984) Pathway for uncoupler-induced calcium efflux in rat liver mitochondria: inhibition by ruthenium red. Biochemistry 23 1645. PMID: 6202317.
If you know of a relevant reference for Ruthenium Red please let us know.
Citations are publications that use Tocris products. Selected citations for Ruthenium Red include:
Ferdek et al (2017) BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell.Death.Dis. 8. PMID: 28252652.
Russo et al (2016) Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides The Journal of Immunology 197 1353. PMID: 27385780.
Merino et al (2015) Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. Neuroreport 10 e0132884. PMID: 26222156.
Shi et al (2015) Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. Proc Natl Acad Sci U S A 21 4852. PMID: 25944998.
Lee et al (2014) Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. PLoS One 111 E5114. PMID: 25385580.
Nesuashvili et al (2013) Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels. Mol Pharmacol 83 1007. PMID: 23444014.
Albert et al (2012) TRPV4 channels mediate the infrared laser-evoked response in sensory neurons. J Neurophysiol 107 3227. PMID: 22442563.
Kaszás et al (2012) Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. J Neurosci 340 152. PMID: 22005042.
Jacques-Fricke et al (2006) Ca2+ influx through mechanosensitive channels inhibits neurite outgrowth in opposition to other influx pathways and release from intracellular stores. World J Gastroenterol 26 5656. PMID: 16723522.
Moran et al (2004) Opioid-like actions of neuropeptide Y in rat substantia gelatinosa: Y1 suppression of inhibition and Y2 suppression of excitation. J Neurophysiol 92 3266. PMID: 15295007.
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Keywords: Ruthenium Red, supplier, inhibitors, inhibits, ryanodine-sensitive, Ca2+, release, mitochondrial, reuptake, Blockers, capsaicin-activated, cation, channels, Non-Selective, Vanillioid, Receptors, VR1, TRPV, Transient, Receptor, Potential, CaV, P-Type, N-Type, voltage-gated, voltage-dependent, Tocris Bioscience, Voltage-gated Calcium Channel (CaV) Blocker products