Cat. No. 1435
Chemical Name: 9-(Tetrahydro-2-furanyl)-9H-purin-6
Biological ActivityInhibitor of adenylyl cyclase (IC50 = 1.4 μM). Inhibits PGE1-stimulated increases in cAMP levels in intact human platelets.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hourani et al (2001) Role of cyclic nucleotides in vasodilations of the rat thoracic aorta induced by adenosine analogues. Br.J.Pharmacol. 133 833. PMID: 11454656.
Fabbri et al (1991) Inhibition of adenylate cyclase of catfish and rat hepatocyte membranes by 9-(tetrahydro-2-furyl)adenine (SQ 22536). J.Enzyme Inhib. 5 87. PMID: 1669444.
Harris et al (1979) Inhibition of adenylate cyclase in human blood platelets by 9-substituted adenine derivatives. J.Cyclic Nucleotide Res. 5 125. PMID: 221552.
If you know of a relevant reference for SQ 22536 please let us know.
Citations are publications that use Tocris products. Selected citations for SQ 22536 include:
Olesen et al (2016) The Vasopressin Type-2 Receptor and Prostaglandin Receptors EP2 and EP4 can Increase Aquaporin-2 Plasma Membrane Targeting Through a cAMP Independent Pathway. American Journal of Physiology - Renal Physiology. PMID: 27558562.
Tang et al (2014) Lactate-mediated glia-neuronal signalling in the mammalian brain. Nat Commun 5 3284. PMID: 24518663.
Tao et al (2013) cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia. Biochim Biophys Acta 8 e71441. PMID: 23951163.
Babu et al (2012) Genistein prevents hyperglycemia-induced monocyte adhesion to human aortic endothelial cells through preservation of the cAMP signaling pathway and ameliorates vascular inflammation in obese diabetic mice. J Nutr 142 724. PMID: 22399524.
Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984. PMID: 21143600.
Morris et al (2009) C5a mediates peripheral blood neutrophil dysfunction in critically ill patients. Am J Respir Crit Care Med 180 19. PMID: 19324972.
Bhanu et al (2008) Inhibition of erythroblast growth and fetal hemoglobin production by ribofuranose-substituted adenosine derivatives. PLoS One 1782 504. PMID: 18586086.
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Keywords: SQ 22536, supplier, Adenylyl, cyclase, inhibitors, inhibits, Cyclases, adenylate, SQ22536, Tocris Bioscience, Adenylyl Cyclase Inhibitor products