S-Trityl-L-cysteine

Cat. No. 2191

S-Trityl-L-cysteine C22H21NO2S [2799-07-7]

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Alternative Name: NSC 83265

Chemical Name: S-(Triphenylmethyl)-L-cysteine

Biological Activity

Potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC50 of 700 nM. Displays antitumor activity.

Technical Data

M.Wt:
363.47
Formula:
C22H21NO2S
Solubility:
Soluble to 50 mM in DMSO
Storage:
Store at +4°C
CAS No:
2799-07-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Brier et al (2004) Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of mitotic kinesin Eg5. Biochemistry 43 13072. PMID: 15476401.

DeBonis et al (2004) In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumour activities. Mol.Cancer Ther. 3 1079. PMID: 15367702.

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Citations are publications that use Tocris products. Selected citations for S-Trityl-L-cysteine include:

Hégarat et al (2014) PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit. J Pharmacol Exp Ther 10 e1004004. PMID: 24391510.

Müllers et al (2014) Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase. PLoS Genet 13 2733. PMID: 25486360.

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Keywords: S-Trityl-L-cysteine, supplier, Potent, selective, inhibitors, inhibits, mitotic, kinesin, Eg5, Mitotic, Kinesin, Mitosis, NSC83265, Tocris Bioscience, Kinesin Inhibitor products

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