S-Trityl-L-cysteine

Cat. No. 2191

S-Trityl-L-cysteine C22H21NO2S [2799-07-7]

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Alternative Name: NSC 83265

Chemical Name: S-(Triphenylmethyl)-L-cysteine

Biological Activity

Potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC50 of 700 nM. Displays antitumor activity.

Technical Data

M.Wt:
363.47
Formula:
C22H21NO2S
Solubility:
Soluble to 50 mM in DMSO
Storage:
Store at +4°C
CAS No:
2799-07-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Brier et al (2004) Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of mitotic kinesin Eg5. Biochemistry 43 13072. PMID: 15476401.

DeBonis et al (2004) In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumour activities. Mol.Cancer Ther. 3 1079. PMID: 15367702.

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Keywords: S-Trityl-L-cysteine, supplier, Potent, selective, inhibitors, inhibits, mitotic, kinesin, Eg5, Mitotic, Kinesin, Mitosis, NSC83265, Tocris Bioscience, Kinesin Inhibitor products

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