Cat. No. 2191

S-Trityl-L-cysteine C22H21NO2S [2799-07-7]

Price and Availability

For S-Trityl-L-cysteine pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: NSC 83265

Chemical Name: S-(Triphenylmethyl)-L-cysteine

Biological Activity

Potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC50 of 700 nM. Displays antitumor activity.

Technical Data

Soluble to 50 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Brier et al (2004) Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of mitotic kinesin Eg5. Biochemistry 43 13072. PMID: 15476401.

DeBonis et al (2004) In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumour activities. Mol.Cancer Ther. 3 1079. PMID: 15367702.

If you know of a relevant reference for S-Trityl-L-cysteine please let us know.

Citations are publications that use Tocris products. Selected citations for S-Trityl-L-cysteine include:

Hengeveld  (2017) Inner centromere localization of the CPC maintains centromere cohesion and allows mitoticcheckpoint silencing. Nat Commun 8 15542. PMID: 28561035.

Hégarat et al (2014) PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit. J Pharmacol Exp Ther 10 e1004004. PMID: 24391510.

Müllers et al (2014) Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase. PLoS Genet 13 2733. PMID: 25486360.

Do you know of a great paper that uses S-Trityl-L-cysteine from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: S-Trityl-L-cysteine, supplier, Potent, selective, inhibitors, inhibits, mitotic, kinesin, Eg5, Mitotic, Kinesin, Mitosis, NSC83265, Tocris Bioscience, Kinesin Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

New Products in this Area

NMS 873

Potent and selective p97 ATPase (VCP) allosteric inhibitor

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.