D609

Cat. No. 1437

D609 C11H15OS2K [83373-60-8]

Price and Availability

For D609 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: O-(Octahydro-4,7-methano-1H-inden-5-yl) carbonopotassium dithioate

Biological Activity

Selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM); antiviral and antitumor agent. Suppresses LPS- and IFNγ-induced NO production (IC50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo.

Technical Data

M.Wt:
266.46
Formula:
C11H15OS2K
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
83373-60-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Zhou et al (2001) D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant. J.Pharmacol.Exp.Ther. 298 103. PMID: 11408530.

Li et al (1998) Phosphatidylcholine-specific phospholipase C regulates glutamate-induced nerve cell death. Proc.Natl.Acad.Sci.U.S.A. 95 7748. PMID: 9636222.

Amtmann (1996) The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C. Drugs Exp.Clin.Res. 22 287. PMID: 9034754.

Tschiakowsky et al (1994) Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609). Br.J.Pharmacol. 113 664. PMID: 7532078.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for D609 include:

Navratil et al (2014) Francisella tularensis LVS induction of prostaglandin biosynthesis by infected macrophages requires specific host phospholipases and lipid phosphatases. Infect Immun 82 3299. PMID: 24866789.

Do you know of a great paper that uses D609 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: D609, supplier, Selective, PC-PLC, inhibitors, inhibits, Phospholipases, C, Esterases, Tocris Bioscience, Phospholipase Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

New Therapies and Challenges in Asthma

Written by Peter J. Barnes

Asthma Life Science Poster

Our Asthma poster highlights key pathways and new therapies used to treat asthma, including those currently in clinical development. Request copy today.

divider line

New Products in this Area

XEN 445

Selective endothelial lipase inhibitor; orally bioavailable

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Screening librairies

Innovation in Design, Supply & Acquisition for Compound Screening Librairies

September 14, 2016

Hatfield, UK