SR 27897

Cat. No. 2190

SR 27897 C20H14ClN3O3S [136381-85-6]

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Alternative Name: Lintitript

Chemical Name: 2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid

Biological Activity

Potent, non-peptide CCK1 receptor antagonist that displays > 33-fold selectivity over CCK2 receptors (EC50 values are 6 and 200 nM respectively). Causes an increase in plasma leptin levels and increases food intake in rats in vivo.

Technical Data

M.Wt:
411.86
Formula:
C20H14ClN3O3S
Solubility:
Soluble to 50 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
136381-85-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Cano et al (2003) Regulation of leptin distribution between plasma and cerebrospinal fluid by cholecystokinin receptors. Br.J.Pharmacol. 140 647. PMID: 14534148.

Gouldson et al (1999) Contrasting roles of Leu356 in the human CCK1 receptor for antagonist SR 27897 and agonist SR 146131 binding. Eur.J.Pharmacol. 383 339. PMID: 10594328.

Gully et al (1993) Peripheral biological activity of SR 27897: a new potent non-peptide antagonist of CCKA receptors. Eur.J.Pharmacol. 23 232.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for SR 27897 include:

Wu et al (2014) Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. Toxicol Sci 138 278. PMID: 24385417.

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Keywords: SR 27897, supplier, Potent, selective, CCK1, antagonists, Cholecystokinin1, Receptors, CCK, Cholecystokinin, SR27897, Tocris Bioscience, CCK1 Receptor Antagonist products

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