Amyloid β-Peptide (1-42) (human)

Cat. No. 1428

Amyloid b-peptide (1-42) (human) Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

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Biological Activity

Human form of the predominant amyloid β-peptide found in the brains of patients with Alzheimer's disease. Downregulates bcl-2 and increases the levels of bax. Neurotoxic. Control peptide (Cat. No. 3391) also available.

Technical Data

M.Wt:
4514.08
Formula:
C203H311N55O60S
Sequence:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Solubility:
Soluble to 1 mg/ml in 50mM Tris buffer
Storage:
Desiccate at -20°C
CAS No:
107761-42-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
Select another batch:

Paradis et al (1996) Amyloid beta peptide of Alzheimer's disease downregulates bcl-2 and upregulates bax expression in human neurons. J.Neurosci. 16 7533. PMID: 8922409.

Van Nostrand et al (1996) Amyloid β-protein induces the cerebrovascular cellular pathology of Alzheimer's disease and related disorders. Ann.N.Y.Acad.Sci. 777 297. PMID: 8624102.

Glenner and Wong (1984) Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem.Biophys.Res.Commun. 120 885. PMID: 6375662.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Amyloid β-Peptide (1-42) (human) include:

Hui et al (2016) Non-Neuronal Cells Are Required to Mediate the Effects of Neuroinflammation: Results from a Neuron-Enriched Culture System. PLoS One 11 e0147134. PMID: 26788729.

Pourbadie et al (2015) Preventing effect of L-type calcium channel blockade on electrophysiological alterations in dentate gyrus granule cells induced by entorhinal amyloid pathology. J Neuroinflammation 10 e0117555. PMID: 25689857.

Deléglise et al (2014) β-amyloid induces a dying-back process and remote trans-synaptic alterations in a microfluidic-based reconstructed neuronal network. Acta Neuropathol Commun 2 145. PMID: 25253021.

Scuderi et al (2012) Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α. Dent Res J (Isfahan) 9 49. PMID: 22405189.

Do you know of a great paper that uses Amyloid β-Peptide (1-42) (human) from Tocris? If so please let us know.show all ▼show less ▲

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