Citalopram hydrobromide

Cat. No. 1427

Citalopram hydrobromide C20H21FN2O.HBr [59729-32-7]

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Chemical Name: 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide

Biological Activity

Highly selective and potent 5-HT uptake inhibitor with no effect on noradrenalin or dopamine uptake (IC50 values are 1.8, 8800 and 41000 nM respectively). Has negligible activity at a wide range of receptors.

Technical Data

M.Wt:
405.31
Formula:
C20H21FN2O.HBr
Solubility:
Soluble to 50 mM in ethanol and to 10 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
59729-32-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Mateo et al (2000) Inhibition of 5-hydroxytryptamine reuptake by the antidepressant citalopram in the locus coeruleus modulates the rat brain noradrenergic transmission in vivo. Neuropharmacology 39 2036. PMID: 10963747.

Auerbach and Hjorth (1995) Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor citalopram on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo. Naunyn Schmiedebergs Arch.Pharmacol. 352 597. PMID: 9053730.

Hyttel (1982) Citalopram - pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog.Drug Metabolism. Eds. Bridges, J. W. & Ch 6 277.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Citalopram hydrobromide include:

Jury et al (2015) Enhanced responsiveness to selective serotonin reuptake inhibitors during lactation. PLoS One 10 e0117339. PMID: 25689282.

Murray et al (2010) Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med 16 694. PMID: 20512126.

Maciag et al (2006) Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry. Neuropsychopharmacology 31 47. PMID: 16012532.

Maciag et al (2006) Evidence that the deficit in sexual behavior in adult rats neonatally exposed to citalopram is a consequence of 5-HT1 receptor stimulation during development. Brain Res 1125 171. PMID: 17101120.

Do you know of a great paper that uses Citalopram hydrobromide from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Citalopram hydrobromide, supplier, potent, selective, 5-HT, reuptake, inhibitors, inhibits, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, Tocris Bioscience, 5-HT Transporter Inhibitor products

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