(S)-(+)-Dimethindene maleate

Cat. No. 1425

(S)-(+)-Dimethindene maleate C20H24N2.C4H4O4 [136152-65-3]

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Chemical Name: N,N-Dimethyl-3-[(1S)-1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine maleate

Biological Activity

Enantiomer that is a subtype-selective M2 muscarinic receptor antagonist (pKi values are 7.08, 7.78, 6.70 and 7.00 for M1, M2, M3 and M4 receptors respectively). Also H1 histamine receptor antagonist (pKi = 7.48).

Technical Data

M.Wt:
408.5
Formula:
C20H24N2.C4H4O4
Solubility:
Soluble to 100 mM in water with gentle warming
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
136152-65-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Lambrecht et al (1999) Neuronal soma-dendritic and prejunctional M1-M4 receptors in gastrointestinal and genitourinary smooth muscle. Life Sci. 64 403. PMID: 10069503.

Pfaff et al (1995) The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor antagonist. Eur.J.Pharmacol. 286 229. PMID: 8608784.

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Keywords: (S)-(+)-Dimethindene maleate, supplier, H1, antagonists, M2, muscarinic, Receptors, Histamine, Acetylcholine, ACh, histaminergic, Tocris Bioscience, M2 Receptor Antagonist products

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