Cat. No. 1422

DCEBIO C9H8Cl2N2O [60563-36-2]

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Chemical Name: 5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one

Biological Activity

Stimulates Cl- secretion via the activation of hKCa3.1 (IK1) potassium channels and an apical Cl- conductance carried by the CFTR channel. More potent than its analog 1-EBIO (Cat. No. 1041).

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Hamilton and Kiessling et al (2006) DCEBIO stimulates Cl- secretion in the mouse jejunum. Am.J.Physiol.Cell Physiol. 290 152. PMID: 16135545.

Singh et al (2001) Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J.Pharmacol.Exp.Ther. 296 600. PMID: 11160649.

If you know of a relevant reference for DCEBIO please let us know.

Citations are publications that use Tocris products. Selected citations for DCEBIO include:

McCully et al (2015) Skin Metabolites Define a New Paradigm in the Localization of Skin Tropic Memory T Cells. J Immunol 195 96. PMID: 26002980.

Laube et al (2013) Benzimidazolones enhance the function of epithelial Na+ transport. Br J Pharmacol 168 1329. PMID: 23083067.

MacVinish et al (2007) Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTR. J Reprod Dev 150 1055. PMID: 17339840.

Do you know of a great paper that uses DCEBIO from Tocris? If so please let us know.

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Keywords: DCEBIO, supplier, potent, Activators, hIK1/Cl-, conductance, K+, channels, Potassium, KCa, KCa3.1, Channels, ca2+-activated, ca2+-dependent, Chloride, Tocris Bioscience, CFTR Activator products

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