Ro 0437626

Cat. No. 2188

Ro 0437626 C27H35N5O4S [134362-79-1]

Price and Availability

For Ro 0437626 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-[(1R)-2-[[(1S,2R,3S)-1-(Cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]amino]-2-oxo-1-(4-thiazolylmethyl)ethyl]-1H-benzimidazole-2-carboxamide

Biological Activity

Selective P2X1 purinergic receptor antagonist (IC50 = 3 μM) that displays > 30-fold selectivity over P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM).

Technical Data

M.Wt:
525.66
Formula:
C27H35N5O4S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
134362-79-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Ford et al (2006) Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br.J.Pharmacol. 147 S132. PMID: 16465177.

Jaime-Figueroa et al (2005) Discovery and synthesis of a novel and selective drug-like P2X1 antagonist. Bioorg.Med.Chem.Lett. 15 3292. PMID: 15927468.

King et al (2004) Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats. Br.J.Pharmacol. 142 519. PMID: 15148261.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Ro 0437626 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Ro 0437626, supplier, Selective, P2X1, antagonists, P2X, Receptors, Purinergic, purinoceptors, Ro0437626, Tocris Bioscience, Purinergic (P2X) Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

P2 Receptors Review

Written by Kenneth Jacobson

P2X and P2Y Receptors Scientific Review

Our Purine Receptor review gives an overview of the subtypes and structures of the P2 receptor family, and the pharmacological ligands used to study them. Request copy or view PDF today.

divider line

Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.