PPNDS

Cat. No. 1309

PPNDS C18H11N4Na4O14PS2 [1021868-77-8]

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Chemical Name: Pyridoxal-5'-phosphate-6-(2'-naphthylazo-6'-nitro-4',8'-disulfonate) tetrasodium salt

Biological Activity

Potent and selective P2X1 receptor antagonist (pKB = 7.43 in rat vas deferens). Up to 52-fold selective over P2Y1 receptors, and selective over ecto-nucleotidase, α1A-adrenoceptors, A1, A2B, H1 and M3 receptors.

Technical Data

M.Wt:
694.36
Formula:
C18H11N4Na4O14PS2
Solubility:
Soluble to 100 mM in water
Storage:
Desiccate at -20°C
CAS No:
1021868-77-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Lambrecht et al (2000) The novel pyridoxal-5'-phosphate derivative PPNDS potently antagonizes activation of P2X1 receptors. Eur.J.Pharmacol. 387 R19. PMID: 10650184.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for PPNDS include:

Madoux et al (2014) Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β. Biopolymers 102 396. PMID: 25048711.

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View Related Products by Product Action

Keywords: PPNDS, supplier, Potent, selective, P2X1, antagonists, Receptors, Purinergic, purinoceptors, Tocris Bioscience, Purinergic (P2X) Receptor Antagonist products

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