Cat. No. 2187
Chemical Name: 4,6-Bis(benzoylamino)-1,3-benzenedi
Biological ActivitySelective non-competitive kainate receptor antagonist; displays selectivity for GLUK5 subunit-containing receptors (IC50 values are 1.6 and > 30 μM for homomeric GLUK5 and GLUK6 receptors respectively). Has minimal activity at AMPA and NMDA receptors (IC50> 30 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Christensen et al (2004) In vitro characterization of 5-carboxyl-2,4-di-benzamido-benzoic acid (NS3763), a noncompetitive antagonist of GLUK5 receptors. J.Pharmacol.Exp.Ther. 309 1003. PMID: 14985418.
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Keywords: NS 3763, supplier, Selective, non-competitive, kainate, antagonists, selective, GLUK5, Glutamate, Kainate, Receptors, iGluR, Ionotropic, NS3763, Tocris Bioscience, Kainate Receptor Antagonist products
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