Cat. No. 2186
Chemical Name: 2'-Fluoro-N-(4-hydroxyphenyl)-[1,1'-b
Biological ActivityNon-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent Ki = 330 nM). Does not inhibit p38α-mediated phosphorylation of MBP and ATF-2. Also tubulin polymerization inhibitor. Cytotoxic in glioblastoma cells at concentrations that do not affect the MK2 pathway.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Gurgis et al (2015) Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2. Cell Death Discovery 1 15028.
Davidson et al (2004) Discovery and characterisation of a substrate selective p38α inhibitor. Biochemistry 43 11658. PMID: 15362850.
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Citations are publications that use Tocris products. Selected citations for CMPD-1 include:
Breindel et al (2013) EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. Cancer Res 73 5053. PMID: 23794705.
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Keywords: CMPD-1, supplier, Non-ATP-competitive, p38α, p38alpha, inhibitors, inhibits, Mitogen-Activated, Protein, Kinase, p38, MAPK, Kinases, Signaling, Signalling, Tocris Bioscience, p38 MAPK Inhibitor products
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