NSC 146109 hydrochloride

Cat. No. 2185

NSC 146109 hydrochloride C17H16N2S.HCl [59474-01-0]

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Chemical Name: (10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride

Biological Activity

Cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases levels of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. Displays some selectivity for tumor cells vs. normal cells in an MTT cell viability assay.

Technical Data

M.Wt:
316.85
Formula:
C17H16N2S.HCl
Solubility:
Soluble to 10 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
59474-01-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Berkson et al (2005) Pilot screening programme for small molecule activators of p53. Int.J.Cancer 115 701. PMID: 15729694.

Dolma et al (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3 285. PMID: 12676586.

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