Cat. No. 0107
Chemical Name: L-(+)-2-Amino-5-phosphonopentanoic acid
Biological ActivityNMDA antagonist. Also agonist at quisqualate-sensitized AP6 site, where it is more potent than the isomer D-AP5 (Cat. No. 0106). Mixture DL-AP5 (Cat. No. 3693) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Schulte et al (1994) Utilization of the resolved L-isomer fo 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 649 203. PMID: 7953634.
Davies and Watkins (1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235 378. PMID: 6145492.
Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65. PMID: 7042024.
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Citations are publications that use Tocris products. Selected citations for L-AP5 include:
Kinney (2005) GAT-3 transporters regulate inhibition in the neocortex. J Neurophysiol 94 4533. PMID: 16135550.
Fernández-Monreal et al (2004) Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signaling. J Biol Chem 279 50850. PMID: 15448144.
Do you know of a great paper that uses L-AP5 from Tocris? If so please let us know.
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Keywords: L-AP5, supplier, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGlu, Ionotropic, Tocris Bioscience, NMDA Receptor Antagonist products