Cat. No. 0106

D-AP5 C5H12NO5P [79055-68-8]

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Alternative Names: 2-APV, D-APV, D-2-amino-5-phosphonovalerate

Chemical Name: D-(-)-2-Amino-5-phosphonopentanoic acid

Biological Activity

Widely used competitive NMDA antagonist. More active form of AP5. Also agonist at quisqualate-sensitized AP6 site where it is less potent than the L-isomer, L-AP5 (Cat. No. 0107). Also available as part of the Mixed NMDA Receptor Tocriset™ or as a mixed isomer DL-AP5 (Cat. No. 0105).

Technical Data

Soluble to 100 mM in water
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Schulte et al (1994) Utilization of the resolved L-isomer fo 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 649 203. PMID: 7953634.

Davies and Watkins (1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235 378. PMID: 6145492.

Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65. PMID: 7042024.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for D-AP5 include:

Sinnayah et al (NULL) Feeding induced by cannabinoids is mediated independently of the melanocortin system. PLoS One 3 e2202. PMID: 18493584.

Dennis et al (2016) Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus. Cereb Cortex 26 414. PMID: 26472558.

Park et al (2016) Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus. J Neurosci 36 622. PMID: 26758849.

Patel et al (2016) Context-Dependent Modulation of GABAAR-Mediated Tonic Currents. J Neurosci 36 607. PMID: 26758848.

Arama et al (2015) GABAA receptor activity shapes the formation of inhibitory synapses between developing medium spiny neurons. Front Cell Neurosci 9 290. PMID: 26300728.

Baltz and Voigt (2015) Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission. Front Cell Neurosci 9 272. PMID: 26236196.

Baquero et al (2015) Developmental changes in synaptic distribution in arcuate nucleus neurons. J Neurosci 35 8558. PMID: 26041922.

Birnbaum et al (2015) Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss. Cell Death Dis 6 e1791. PMID: 26086964.

Brzosko et al (2015) Retroactive modulation of spike timing-dependent plasticity by dopamine. Elife 4. PMID: 26516682.

Campbell et al (2015) GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy. Glia 63 23. PMID: 25066727.

Campbell et al (2015) Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia. Front Cell Neurosci 8 425. PMID: 25565960.

Ciani et al (2015) Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1. Nat Commun 6 8302. PMID: 26400647.

Cooke et al (2015) Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1. Nat Neurosci 18 262. PMID: 25599221.

Costa et al (2015) Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome. Front Behav Neurosci 9 65. PMID: 25814945.

Cramer et al (2015) Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. J Neurosci 35 5664. PMID: 25855180.

Curcio et al (2015) Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons. Cell Death Dis 6 e1645. PMID: 25675305.

Dilger et al (2015) Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement. J Neurosci 35 3652. PMID: 25716863.

Dorris et al (2015) Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons. J Neurophysiol 113 720. PMID: 25376786.

Duménieu et al (2015) Afterhyperpolarization (AHP) regulates the frequency and timing of action potentials in the mitral cells of the olfactory bulb: role of olfactory experience. Physiol Rep 3. PMID: 26019289.

Eckel et al (2015) Activation of calcineurin underlies altered trafficking of α2 subunit containing GABAA receptors during prolonged epileptiform activity. Neuropharmacology 88 82. PMID: 25245802.

Gao et al (2015) Dendritic morphology, synaptic transmission, and activity of mature granule cells born following pilocarpine-induced status epilepticus in the rat. Front Cell Neurosci 9 384. PMID: 26500490.

Garthwaite et al (2015) Nitric oxide targets oligodendrocytes and promotes their morphological differentiation. Glia 63 383. PMID: 25327839.

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580. PMID: 26134641.

Ghosh et al (2015) Norepinephrine Modulates Pyramidal Cell Synaptic Properties in the Anterior Piriform Cortex of Mice: Age-Dependent Effects of β-adrenoceptors. Front Cell Neurosci 9 450. PMID: 26635530.

Haselmann et al (2015) Interactions of Human Autoantibodies with Hippocampal GABAergic Synaptic Transmission - Analyzing Antibody-Induced Effects ex vivo. Front Neurol 6 136. PMID: 26124746.

Hososhima et al (2015) Kinetic evaluation of photosensitivity in bi-stable variants of chimeric channelrhodopsins. PLoS One 10 e0119558. PMID: 25789474.

Hou et al (2015) MicroRNA miR124 is required for the expression of homeostatic synaptic plasticity. Nat Commun 6 10045. PMID: 26620774.

John et al (2015) Functional α7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus. Brain Res 1601 15. PMID: 25553616.

Kardamakis et al (2015) Tectal microcircuit generating visual selection commands on gaze-controlling neurons. Proc Natl Acad Sci U S A 112 E1956. PMID: 25825743.

Lamanna et al (2015) A pre-docking source for the power-law behavior of spontaneous quantal release: application to the analysis of LTP. Front Cell Neurosci 9 44. PMID: 25741239.

Lee et al (2015) Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility. Mol Brain 8 38. PMID: 26104314.

Li et al (2015) The Posterodorsal Medial Amygdala Regulates the Timing of Puberty Onset in Female Rats. Endocrinology 156 3725. PMID: 26252061.

Liu et al (2015) Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats. J Biomed Sci 22 79. PMID: 26385355.

Malvaez et al (2015) Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions. Sci Rep 5 12511. PMID: 26212790.

Mapelli et al (2015) The effect of desflurane on neuronal communication at a central synapse. PLoS One 10 e0123534. PMID: 25849222.

Medrihan et al (2015) Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse. Cereb Cortex 25 3356. PMID: 24962993.

Morini et al (2015) Subventricular zone neural progenitors reverse TNF-α effects in cortical neurons. Stem Cell Res Ther 6 166. PMID: 26345473.

Morrie and Feller (2015) An Asymmetric Increase in Inhibitory Synapse Number Underlies the Development of a Direction Selective Circuit in the Retina. J Neurosci 35 9281. PMID: 26109653.

Noh et al (2015) ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons. Proc Natl Acad Sci U S A 112 6820. PMID: 25538301.

Pardi et al (2015) Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain. Elife 4 e08764. PMID: 26163657.

Park et al (2015) Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors. Mol Brain 8 7. PMID: 25645137.

Pasca et al (2015) Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture. Nat Methods 12 671. PMID: 26005811.

Polito et al (2015) Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). Eneuro 2. PMID: 26465004.

Puranam et al (2015) Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus. J Neurosci 35 8866. PMID: 26063919.

Reifler et al (2015) The rat retina has five types of ganglion-cell photoreceptors. Exp Eye Res 130 17. PMID: 25450063.

Rosa et al (2015) Neuron-glia signaling in developing retina mediated by neurotransmitter spillover. Elife 4. PMID: 26274565.

Savotchenko et al (2015) Neuraminidase inhibition primes short-term depression and suppresses long-term potentiation of synaptic transmission in the rat hippocampus. Neural Plast 2015 908190. PMID: 25802763.

Sengupta and Thirumalai (2015) AMPA receptor mediated synaptic excitation drives state-dependent bursting in Purkinje neurons of zebrafish larvae. Elife 4. PMID: 26416140.

Sexton and Gelder (2015) G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells. PLoS One 10 e0128690. PMID: 26069965.

Sharma et al (2015) Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor κ B. Sci Rep 5 16616. PMID: 26577291.

Sobieski et al (2015) Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro. J Neurosci 35 11105. PMID: 26245971.

Stephen et al (2015) Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling. J Neurosci 35 15996. PMID: 26631479.

Tang et al (2015) Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex. Sci Rep 5 14099. PMID: 26370265.

Taylor-Burds et al (2015) Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation. PLoS One 10 e0131076. PMID: 26110920.

Telese et al (2015) LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation. Neuron 86 696. PMID: 25892301.

Toda and Huganir (2015) Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38. Proc Natl Acad Sci U S A 112 6712. PMID: 25964356.

Tseng et al (2015) Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors. Proc Natl Acad Sci U S A 112 1214. PMID: 25552561.

Vossel et al (2015) Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β. J Cell Biol 209 419. PMID: 25963821.

Wang et al (2015) Apamin Boosting of Synaptic Potentials in CaV2.3 R-Type Ca2+ Channel Null Mice. PLoS One 10 e0139332. PMID: 26418566.

Williams and Hablitz (2015) Differential modulation of repetitive firing and synchronous network activity in neocortical interneurons by inhibition of A-type K(+) channels and Ih. Front Cell Neurosci 9 89. PMID: 25852481.

Xue et al (2015) Structural elements that underlie Doc2β function during asynchronous synaptic transmission. Proc Natl Acad Sci U S A 112 E4316. PMID: 26195798.

Yan et al (2015) Paclitaxel induces acute pain via directly activating toll like receptor 4. Mol Pain 11 10. PMID: 25868824.

Zhong et al (2015) BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons. J Neurosci 35 4469. PMID: 25762688.

Zhu et al (2015) Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways. J Neurosci 35 621. PMID: 25589756.

Ady et al (2014) Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 δ glutamate receptors. EMBO Rep 15 103. PMID: 24357660.

Albrecht et al (2014) Inhibitory projections from the ventral nucleus of the trapezoid body to the medial nucleus of the trapezoid body in the mouse. Front Neural Circuits 8 83. PMID: 25120436.

Armbrust et al (2014) Mutant β-III spectrin causes mGluR1α mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5. J Neurosci 34 9891. PMID: 25057192.

Bemben et al (2014) CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses. Nat Neurosci 17 56. PMID: 24336150.

Blanco-Suárez et al (2014) Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation. J Cereb Blood Flow Metab 34 1898. PMID: 25248834.

Chuhma et al (2014) Dopamine neurons control striatal cholinergic neurons via regionally heterogeneous dopamine and glutamate signaling. Neuron 81 901. PMID: 24559678.

Cijsouw et al (2014) Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner. J Cell Biol 204 759. PMID: 24590174.

Crook et al (2014) A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate retina. Vis Neurosci 31 57. PMID: 24801624.

Dale et al (2014) Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus. J Psychopharmacol 28 891. PMID: 25122043.

Gaffaney et al (2014) Mutations that disrupt Ca2+-binding activity endow Doc2β with novel functional properties during synaptic transmission. Mol Biol Cell 25 481. PMID: 24356452.

He and Bausch (2014) Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic memantine treatment in an in vitro model of limbic epileptogenesis. Neuropharmacology 77 379. PMID: 24184417.

Hodges et al (2014) α-Actinin-2 mediates spine morphology and assembly of the post-synaptic density in hippocampal neurons. PLoS One 9 e101770. PMID: 25007055.

Ivanov et al (2014) Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices. J Cereb Blood Flow Metab 34 397. PMID: 24326389.

Lee et al (2014) Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase. Philos Trans R Soc Lond B Biol Sci 369 20130158. PMID: 24298159.

Mirante et al (2014) Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala. Front Mol Neurosci 7 62. PMID: 25071439.

Mohn et al (2014) Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities. Mol Psychiatry 19 1133. PMID: 24934177.

Ostrowski et al (2014) Depressed GABA and glutamate synaptic signaling by 5-HT1A receptors in the nucleus tractus solitarii and their role in cardiorespiratory function. J Neurophysiol 111 2493. PMID: 24671532.

Pan et al (2014) Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits. J Clin Invest 124 4629. PMID: 25202982.

Prabakaran et al (2014) Quantitative profiling of peptides from RNAs classified as noncoding. Nat Commun 5 5429. PMID: 25403355.

Qi et al (2014) Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aβ-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aβ agents. Acta Neuropathol Commun 2 175. PMID: 25540024.

Sánchez-Blázquez et al (2014) The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. Int J Neuropsychopharmacol 17 1943. PMID: 24485144.

Simma et al (2014) NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells. Cell Commun Signal 12 75. PMID: 25477292.

Varodayan and Harrison (2014) HSF1 transcriptional activity mediates alcohol induction of Vamp2 expression and GABA release. Front Integr Neurosci 7 89. PMID: 24376402.

Wang et al (2014) Accumulation of GABAergic neurons, causing a focal ambient GABA gradient, and downregulation of KCC2 are induced during microgyrus formation in a mouse model of polymicrogyria. Cereb Cortex 24 1088. PMID: 23246779.

Woo et al (2014) Isoliquiritigenin, a chalcone compound, enhances spontaneous inhibitory postsynaptic response. Exp Neurobiol 23 163. PMID: 24963281.

Akrouh and Kerschensteiner (2013) Intersecting circuits generate precisely patterned retinal waves. Neuron 79 322. PMID: 23830830.

Alpert and Alford (2013) Synaptic NMDA receptor-dependent Ca2+ entry drives membrane potential and Ca2+ oscillations in spinal ventral horn neurons. PLoS One 8 e63154. PMID: 23646190.

Berlinguer-Palmini et al (2013) GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses. PLoS One 8 e82180. PMID: 24312407.

Bernard et al (2013) Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures. Neurobiol Dis 59 42736. PMID: 23831253.

Chen et al (2013) The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse. J Neurosci 33 8336. PMID: 23658173.

Chen and Shen (2013) Modulation of mGluR-dependent MAP1B translation and AMPA receptor endocytosis by microRNA miR-146a-5p. J Neurosci 33 9013. PMID: 23699512.

Cruz et al (2013) Ghrelin increases GABAergic transmission and interacts with ethanol actions in the rat central nucleus of the amygdala. Neuropsychopharmacology 38 364. PMID: 22968812.

Ferando and Mody (2013) Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons. Front Neural Circuits 7 144. PMID: 24062647.

Johnstone and Raymond (2013) Postsynaptic protein synthesis is required for presynaptic enhancement in persistent forms of long-term potentiation. Front Synaptic Neurosci 5 1. PMID: 23450328.

Korb et al (2013) Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity. Nat Neurosci 16 874. PMID: 23749147.

Medrihan et al (2013) Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels. Nat Commun 4 1512. PMID: 23443540.

Neuser et al (2013) Region-specific integration of embryonic stem cell-derived neuronal precursors into a pre-existing neuronal circuit. PLoS One 8 e66497. PMID: 23840491.

Pi et al (2013) Cortical interneurons that specialize in disinhibitory control. Nature 503 521. PMID: 24097352.

Pribiag and Stellwagen (2013) TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors. J Neurosci 33 15879. PMID: 24089494.

Rompala et al (2013) Contribution of NMDA receptor hypofunction in prefrontal and cortical excitatory neurons to schizophrenia-like phenotypes. PLoS One 8 e61278. PMID: 23613827.

Sakaba et al (2013) Fast neurotransmitter release regulated by the endocytic scaffold intersectin. Proc Natl Acad Sci U S A 110 8266. PMID: 23633571.

Siddoway et al (2013) An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. J Neurosci 33 11206. PMID: 23825423.

Song et al (2013) Different transporter systems regulate extracellular GABA from vesicular and non-vesicular sources. Front Cell Neurosci 7 23. PMID: 23494150.

Taylor et al (2013) Axonal translation of β-catenin regulates synaptic vesicle dynamics. J Neurosci 33 5584. PMID: 23536073.

Tokuda et al (2013) Locally-generated Acetaldehyde Contributes to the Effects of Ethanol on Neurosteroids and LTP in the Hippocampus. Neurol Clin Neurosci 1 138. PMID: 24455167.

Vicente-Sánchez et al (2013) HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity. Mol Brain 6 42. PMID: 24093505.

Wang et al (2013) Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons. PLoS One 8 e61787. PMID: 23593498.

Yamagata et al (2013) Regulation of ERK1/2 mitogen-activated protein kinase by NMDA-receptor-induced seizure activity in cortical slices. Brain Res 1507 1. PMID: 23419897.

Yoshii et al (2013) A Myosin Va mutant mouse with disruptions in glutamate synaptic development and mature plasticity in visual cortex. J Neurosci 33 8472. PMID: 23658184.

Yu et al (2013) Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice. PLoS One 8 e76049. PMID: 24069457.

Bajo et al (2012) Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala. Addict Biol 17 694. PMID: 21955024.

Bospoort et al (2012) Munc13 controls the location and efficiency of dense-core vesicle release in neurons. J Cell Biol 199 883. PMID: 23229896.

Caiati et al (2012) Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses. Sci Rep 2 285. PMID: 22368777.

Campbell et al (2012) Human glioma cells induce hyperexcitability in cortical networks. Epilepsia 53 1360. PMID: 22709330.

Crawford et al (2012) Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro. J Neurosci 32 13100. PMID: 22993427.

Daftary et al (2012) Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala. Neuroscience 224 125. PMID: 22917617.

Fortin et al (2012) Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors. J Neurosci 32 8127. PMID: 22699894.

Gaamouch et al (2012) Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity. J Neurosci 32 10767. PMID: 22855824.

Guo et al (2012) Tissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons. Biomaterials 33 5723. PMID: 22594977.

Haam et al (2012) GABA is excitatory in adult vasopressinergic neuroendocrine cells. J Neurosci 32 572. PMID: 22238092.

He et al (2012) Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR. Neuropsychopharmacology 37 1338. PMID: 22218089.

Heinrich et al (2012) K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study. Br J Pharmacol 167 1003. PMID: 22394324.

Hook et al (2012) Dopaminergic modulation of ganglion-cell photoreceptors in rat. Eur J Neurosci 35 507. PMID: 22304466.

Ichinose and Lukasiewicz (2012) The mode of retinal presynaptic inhibition switches with light intensity. J Neurosci 32 4360. PMID: 22457487.

Janssen et al (2012) Neuregulin directly decreases voltage-gated sodium current in hippocampal ErbB4-expressing interneurons. J Neurosci 32 13889. PMID: 23035098.

Kolind et al (2012) Opposing Effects of Intrinsic Conductance and Correlated Synaptic Input on V-Fluctuations during Network Activity. Front Comput Neurosci 6 40. PMID: 22783184.

Lemos et al (2012) Repeated stress dysregulates κ-opioid receptor signaling in the dorsal raphe through a p38α MAPK-dependent mechanism. J Neurosci 32 12325. PMID: 22956823.

Lethbridge et al (2012) Olfactory bulb glomerular NMDA receptors mediate olfactory nerve potentiation and odor preference learning in the neonate rat. PLoS One 7 e35024. PMID: 22496886.

Navarrete et al (2012) Astrocytes mediate in vivo cholinergic-induced synaptic plasticity. PLoS Biol 10 e1001259. PMID: 22347811.

Olsen and Sheng (2012) NMDA receptors and BAX are essential for Aβ impairment of LTP. Sci Rep 2 225. PMID: 22355739.

Platt et al (2012) Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice. PLoS One 7 e36397. PMID: 22570709.

Rodríguez-Muñoz et al (2012) The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control. Neuropsychopharmacology 37 338. PMID: 21814188.

Saliba et al (2012) Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current. EMBO J 31 2937. PMID: 22531784.

Takesian et al (2012) Age-dependent effect of hearing loss on cortical inhibitory synapse function. J Neurophysiol 107 937. PMID: 22090457.

Tang et al (2012) Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid β-protein oligomers. Traffic 13 681. PMID: 22309053.

Udagawa et al (2012) Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex. Mol Cell 47 253. PMID: 22727665.

Upreti et al (2012) Altered neurotransmitter release, vesicle recycling and presynaptic structure in the pilocarpine model of temporal lobe epilepsy. Brain 135 869. PMID: 22344585.

Villers et al (2012) Long-lasting LTP requires neither repeated trains for its induction nor protein synthesis for its development. PLoS One 7 e40823. PMID: 22792408.

Yao et al (2012) Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles. Nat Neurosci 15 243. PMID: 22197832.

Ali (2011) CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1. J Neurophysiol 105 1051. PMID: 21123660.

Bateup et al (2011) Loss of Tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function. J Neurosci 31 8862. PMID: 21677170.

Case et al (2011) Functional refinement in the projection from ventral cochlear nucleus to lateral superior olive precedes hearing onset in rat. PLoS One 6 e20756. PMID: 21694776.

Christie et al (2011) Ca(2+)-dependent enhancement of release by subthreshold somatic depolarization. Nat Neurosci 14 62. PMID: 21170054.

Crawford et al (2011) Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses. J Neurosci 31 979. PMID: 21248122.

Etherton et al (2011) An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus. EMBO J 30 2908. PMID: 21642956.

Goldberg et al (2011) Rapid developmental maturation of neocortical FS cell intrinsic excitability. Cereb Cortex 21 666. PMID: 20705896.

Kaminski et al (2011) 11-Deoxycortisol impedes GABAergic neurotransmission and induces drug-resistant status epilepticus in mice. Neuropharmacology 60 1098. PMID: 20883706.

Lazarevic et al (2011) Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing. J Neurosci 31 10189. PMID: 21752995.

Mahajan et al (2011) Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing. Neuroscience 189 305. PMID: 21620933.

Mark et al (2011) Delayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia phenotypes of genomic Cacna1a mutations. J Neurosci 31 4311. PMID: 21411672.

Meehan et al (2011) A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of levetiracetam. J Neurophysiol 106 1227. PMID: 21653714.

Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984. PMID: 21143600.

Pan et al (2011) Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice. J Neurosci 31 13420. PMID: 21940435.

Parker et al (2011) Attenuating GABA(A) receptor signaling in dopamine neurons selectively enhances reward learning and alters risk preference in mice. J Neurosci 31 17103. PMID: 22114279.

Randall et al (2011) Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro. Eur J Neurosci 33 914. PMID: 21255131.

Ripley et al (2011) Regulation of synaptic stability by AMPA receptor reverse signaling. Proc Natl Acad Sci U S A 108 367. PMID: 21173224.

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Léveillé et al (2008) Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors. FASEB J 22 4258. PMID: 18711223.

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Baldelli et al (2007) Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses. J Neurosci 27 13520. PMID: 18057210.

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Smetana et al (2007) Muscarinic receptor activation elicits sustained, recurring depolarizations in reticulospinal neurons. J Neurophysiol 97 3181. PMID: 17344371.

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