Cat. No. 0102
Chemical Name: D-(-)-2-Amino-4-phosphonobutyric acid
Biological ActivityBroad spectrum excitatory amino acid receptor antagonist. Also agonist at the quisqualate-sensitized AP6 site in hippocampus where it is less potent than L-AP4. DL Mixture (Cat. No. 0101) and L-isomer (Cat. No. 0103) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Schulte et al (1994) Utilization of the resolved L-isomer of 2-amino-6-phosphonhexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 649 203. PMID: 7953634.
Davies and Watkins (1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235 378. PMID: 6145492.
Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65. PMID: 7042024.
If you know of a relevant reference for D-AP4 please let us know.
Citations are publications that use Tocris products. Selected citations for D-AP4 include:
France (2017) Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus. Neuropharmacology 112 76. PMID: 27523302.
Sexton et al (2015) Type I intrinsically photosensitive retinal ganglion cells of early post-natal development correspond to the M4 subtype. Neural Dev 10 17. PMID: 26091805.
Sexton and Gelder (2015) G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells. PLoS One 10 e0128690. PMID: 26069965.
Do you know of a great paper that uses D-AP4 from Tocris? If so please let us know.
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Keywords: D-AP4, supplier, Broad, spectrum, EAA, antagonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, Tocris Bioscience, Non-selective Ionotropic Glutamate Antagonist products