Cat. No. 0101
Chemical Name: DL-2-Amino-4-phosphonobutyric acid
Biological ActivityBroad spectrum EAA ligand. Separate isomers D-AP4 and L-AP4 also available (Cat. No's. 0102 and 0103 respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65. PMID: 7042024.
Evans et al (1979) Antagonism of excitatory amino acid-induced responses and of synaptic excitation in the isolated spinal cord of the frog. Br.J.Pharmacol. 67 591. PMID: 316343.
If you know of a relevant reference for DL-AP4 please let us know.
Citations are publications that use Tocris products. Selected citations for DL-AP4 include:
Schmidt and Kofuji (2011) Structure and function of bistratified intrinsically photosensitive retinal ganglion cells in the mouse. J Comp Neurol 519 1492. PMID: 21452206.
Schmidt and Kofuji (2009) Functional and morphological differences among intrinsically photosensitive retinal ganglion cells. J Neurosci 29 476. PMID: 19144848.
Sekaran et al (2005) Melanopsin-dependent photoreception provides earliest light detection in the mammalian retina. Curr Biol 15 1099. PMID: 15964274.
Do you know of a great paper that uses DL-AP4 from Tocris? If so please let us know.
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Keywords: DL-AP4, supplier, Broad, spectrum, EAA, antagonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, Tocris Bioscience, Non-selective Ionotropic Glutamate Antagonist products
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