Yohimbine hydrochloride

Cat. No. 1127

Yohimbine hydrochloride C21H26N2O3.HCl [65-19-0]

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Chemical Name: 17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride

Biological Activity

α2-adrenoceptor antagonist (pKi values are 8.52, 8.00 and 9.17 for human α2A, α2B and α2C receptors respectively). Diastereomer Rauwolscine hydrochloride (Cat. No. 0891) also available.

Technical Data

Soluble to 25 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Lalchandani et al (2002) Yohimbine dimers exhibiting selectivity for the human α2c-adrenoceptor subtype. J.Pharmacol.Exp.Ther. 303 979. PMID: 12438517.

Redfern and Williams (1995) A re-evaluation of the role of α2-adrenoceptors in the anxiogenic effects of yohimbine, using the selective antagonist delequamine in the rat. Br.J.Pharmacol. 116 2081. PMID: 8640349.

Goldberg and Robertson (1987) Yohimbine: a pharmacological probe for study of the α2-adrenoceptor. Pharmacol.Rev. 35 143.

Doxey et al (1984) Comparison of the α-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine. Naunyn Schmiedebergs Arch.Pharmacol. 325 136. PMID: 6144048.

If you know of a relevant reference for Yohimbine hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for Yohimbine hydrochloride include:

Delaney and Crane (2016) Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels. Sci Rep 6 19255. PMID: 26755335.

Kastman et al (2016) Nucleus incertus Orexin2 receptors mediate alcohol seeking in rats Neuropharmacology 110 82. PMID: 27395787.

Dudek et al (2015) A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity. PLoS One 10 e0141327. PMID: 26506439.

Gazarini et al (2015) PTSD-like memory generated through enhanced noradrenergic activity is mitigated by a dual step pharmacological intervention targeting its reconsolidation. Int J Neuropsychopharmacol 18. PMID: 25539509.

Phelps et al (2015) Psychopharmacological characterisation of the successive negative contrast effect in rats. Proc Natl Acad Sci U S A 232 2697. PMID: 25791190.

Scardochio et al (2015) The Effects of Electrical and Optical Stimulation of Midbrain Dopaminergic Neurons on Rat 50-kHz Ultrasonic Vocalizations. Front Behav Neurosci 9 331. PMID: 26696851.

Soty et al (2015) A gut-brain neural circuit controlled by intestinal gluconeogenesis is crucial in metabolic health. Psychopharmacology (Berl) 4 106. PMID: 25685698.

Ciccocioppo et al (2014) Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat. Neuropsychopharmacology 39 2601. PMID: 24863033.

Corcoran et al (2014) Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice. Mol Metab 34 51. PMID: 24381267.

Costello et al (2014) Comparison of the reinforcing properties of nicotine and cigarette smoke extract in rats. Neuropsychopharmacology 39 1843. PMID: 24513971.

Drake et al (2014) The degree of acute descending control of spinal nociception in an area of primary hyperalgesia is dependent on the peripheral domain of afferent input. J Physiol 592 3611. PMID: 24879873.

Mondal et al (2013) Mechanism of ghrelin-induced gastric contractions in Suncus murinus (house musk shrew): involvement of intrinsic primary afferent neurons. PLoS One 8 e60365. PMID: 23565235.

Ryan et al (2013) Relaxin-3/RXFP3 system regulates alcohol-seeking. Proc Natl Acad Sci U S A 110 20789. PMID: 24297931.

Kim et al (2011) Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation. Brain Res 1384 110. PMID: 21315691.

Barnea et al (2008) The genetic design of signaling cascades to record receptor activation. Proc Natl Acad Sci U S A 105 64. PMID: 18165312.

Maupoil et al (2007) Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors. Br J Pharmacol 150 899. PMID: 17325650.

Marchese et al (2003) Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications. Br J Pharmacol 140 520. PMID: 12970091.

Do you know of a great paper that uses Yohimbine hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Yohimbine hydrochloride, supplier, Selective, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenoceptor, antagonist, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, Receptors, Tocris Bioscience, Adrenergic α2 Receptor Antagonist products

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