8-Bromo-cAMP, sodium salt

Cat. No. 1140

8-Bromo-cAMP, sodium salt C10H10BrN5NaO6P [76939-46-3]

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Chemical Name: 8-Bromoadenosine-3',5'-cyclic monophosphate sodium salt

Biological Activity

Cell-permeable cAMP analog; activator of protein kinase A. Also available as part of the PKA Tocriset™.

Technical Data

M.Wt:
430.09
Formula:
C10H10BrN5NaO6P
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
76939-46-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Wang et al (2011) A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. Stem Cell Rev. 7 331. PMID: 21120637.

Carranza et al (1998) Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells. J.Physiol. 511 235. PMID: 9679177.

Chow et al (1998) Functional modulation of P2X2 receptors by cyclic AMP-dependent protein kinase. J.Neurochem. 70 2606. PMID: 9603227.

Hei et al (1991) Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs. Mol.Pharmacol. 39 233. PMID: 1847496.

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Citations are publications that use Tocris products. Selected citations for 8-Bromo-cAMP, sodium salt include:

Tozzi et al (2015) Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system. Front Cell Neurosci 9 192. PMID: 26074768.

Adelfinger et al (2014) GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization. Biochem Pharmacol 91 369. PMID: 25065880.

Niedenberger et al (2014) Actin dynamics regulate subcellular localization of PALLD in mouse Sertoli cells. Reproduction. PMID: 24989903.

Nakao et al (2012) The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa. PLoS One 7 e32472. PMID: 22485131.

Do you know of a great paper that uses 8-Bromo-cAMP, sodium salt from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: 8-Bromo-cAMP, sodium salt, supplier, Cell-permeable, cAMP, Membrane, permeable, analog, activates, activators, PKA, Cyclic, adenosines, Monophosphate, Inositol, Signaling, Signalling, Protein, Kinase, A, Kinases, Tocris Bioscience, cAMP products

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