Anpirtoline hydrochloride

Cat. No. 0703

Anpirtoline hydrochloride C10H13ClN2S.HCl [99201-87-3]

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Chemical Name: 6-Chloro-2-[piperidinyl-4-thio]pyridine hydrochloride

Biological Activity

Highly potent 5-HT1B receptor agonist (Ki values are 28, 150 and 1490 nM at 5-HT1B, 5-HT1A and 5-HT2 receptors respectively). Decreases central serotonin synthesis and attenuates aggressive behavior in vivo. Also acts as an antagonist at 5-HT3 receptors (Ki = 29.5 nM) and is brain penetrant.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>99 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Watanabe et al (2006) Effects of anpirtoline on regional serotonin synthesis in the rat brain: an autoradiographic study. Nucl.Med.Biol. 33 325. PMID: 16631081.

Almeida and Miczek (2002) Aggression escalates by social instigation or by discontinuation of reinforcement ("frustration") in mice: inhibition by anpirtoline: a 5-HT1B receptor agonist. Neuropsychopharmacology 27 171. PMID: 12093591.

Göthert et al (1995) 5HT3 receptor antagonism by anpirtoline, a mixed 5HT1 receptor agonist/5HT3 receptor antagonist. Br.J.Pharmacol. 114 269. PMID: 7881726.

Swedberg et al (1992) D-16949 (anpirtoline): a novel serotonergic (5-HT1B) psychotherapeutic agent assessed by its discriminative effect in the rat. J.Pharmacol.Exp.Ther. 263 1015. PMID: 1335050.

If you know of a relevant reference for Anpirtoline hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for Anpirtoline hydrochloride include:

Müller et al (2009) 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS One 4 e6453. PMID: 19649285.

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Keywords: Anpirtoline hydrochloride, supplier, potent, 5-HT1B, agonists, 5-HT3, antagonists, Serotonin, Receptors, Tocris Bioscience, 5-HT1B Receptor Agonist products

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