ZK 164015

Cat. No. 2183

ZK 164015 C30H43NO4S [177583-70-9]

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Chemical Name: 2-(4-Hydroxyphenyl)-3-methyl-1-[10-(pentylsulfonyl)decyl]-1H-indol-5-ol

Biological Activity

Potent estrogen receptor silent antagonist. Inhibits 17β-estradiol stimulation of luciferase activity (IC50 = 0.025 μM); potently inhibits the growth of estrogen-sensitive human MCF-7 breast cancer cells in vitro (IC50 ~ 1 nM).

Technical Data

M.Wt:
513.73
Formula:
C30H43NO4S
Solubility:
Soluble to 25 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
177583-70-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Walter et al (2004) Synthesis and biological evaluation of stilbene-based pure estrogen antagonists. Bioorg.Med.Chem.Lett. 14 4659. PMID: 15324884.

Liu et al (1999) The anti-estrogen hydroxytamoxifen is a potent antagonist in a novel yeast system. Biol.Chem. 380 1341. PMID: 10614829.

Biberger and von Angerer (1996) 2-Phenylindoles with sulfur containing side chains. Estrogen receptor affinity, antiestrogenic potency, and antitumour activity. J.Steroid Biochem.Molec.Biol. 58 31.

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Keywords: ZK 164015, supplier, Potent, estrogen, receptor, antagonists, ER, ERR, Estrogen, Receptors, ZK164015, Tocris Bioscience, Estrogen and Related Receptor Antagonist products

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