Amthamine dihydrobromide

Cat. No. 0668

Amthamine dihydrobromide C6H11N3S.2HBr [142457-00-9]

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Chemical Name: 2-Amino-5-(2-aminoethyl)-4-methylthiazole dihydrobromide

Biological Activity

Highly selective H2 agonist, slightly more potent than histamine itself. Only a weak antagonist at H3 and has no activity at H1 receptors. Induces vasodilation of cerebral arteries and decreases myogenic tone in vitro.

Technical Data

Soluble to 100 mM in water
>99 %
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Jarajapu et al (2006) Histamine decreases myogenic tone in rat cerebral arteries by H2-receptor-mediated Kv channel activation, independent of endothelium and cyclic AMP. Eur.J.Pharmacol. 547 116. PMID: 16920098.

Coruzzi et al (1993) The new potent and selective histamine H2 receptor agonist amthamine as a tool to study gastric secretion. Naunyn Schmiedebergs Arch.Pharmacol. 348 77. PMID: 8377843.

Poli et al (1993) In vitro cardiac pharmacology of the new histamine H2 receptor agonist amthamine; comparisons with histamine and dimaprit. Agents Actions 40 44. PMID: 8147269.

Eriks et al (1992) Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazole. J.Med.Chem. 35 3239. PMID: 1507209.

If you know of a relevant reference for Amthamine dihydrobromide please let us know.

Citations are publications that use Tocris products. Selected citations for Amthamine dihydrobromide include:

Saligrama et al (2014) Histamine H2 receptor signaling environment interactions determine susceptibility to experimental allergic encephalomyelitis. FASEB J 28 1898. PMID: 24371118.

Copsel et al (2011) Multidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation. J Biol Chem 286 6979. PMID: 21205825.

Do you know of a great paper that uses Amthamine dihydrobromide from Tocris? If so please let us know.

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Keywords: Amthamine dihydrobromide, supplier, selective, H2, agonists, Receptors, Histamine, histaminergic, Tocris Bioscience, Histamine H2 Receptor Agonist products

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